Numerous light-based diagnostic and therapeutic devices are routinely used in the clinic.
These devices have a familiar look as items plugged in the wall or placed at patients' …

Host immunity recognizes and eliminates most early tumor cells, yet immunological
checkpoints, exemplified by CTLA-4, PD-1, and PD-L1, pose a significant obstacle to …

Chimeric antigen receptor (CAR) T cell-based immunotherapy, approved by the US Food
and Drug Administration, has shown curative potential in patients with haematological …

The recent advances of upconversion nanoparticles (UCNPs) have made them the ideal
“partner” for a variety of biological applications. In this review, we describe the emerging …

Plant-based photosensors, such as the light-oxygen-voltage sensing domain 2 (LOV2) from
oat phototropin 1, can be modularly wired into cell signaling networks to remotely control …

Glioma is the most common intracranial primary malignancy, with limited treatment options
and a poor overall survival (OS). Immunotherapy has been used successfully in various …

We herein report an optogenetically activatable CRISPR-Cas9 nanosystem for
programmable genome editing in the second near-infrared (NIR-II) optical window. The …

The cGAS-STING signaling pathway has emerged as a promising target for immunotherapy
development. Here, we introduce a light-sensitive optogenetic device for control of the …

Optogenetics combines genetics and biophotonics to enable noninvasive control of
biological processes with high spatiotemporal precision. When engineered into protein …

Background: Head and neck squamous cell carcinoma (HNSCC) is the seventh most
common type of cancer worldwide. Its highly aggressive and heterogeneous nature and …