Multifunctional materials for implantable and wearable photonic healthcare devices
Numerous light-based diagnostic and therapeutic devices are routinely used in the clinic.
These devices have a familiar look as items plugged in the wall or placed at patients' …
These devices have a familiar look as items plugged in the wall or placed at patients' …
Immuno-oncology: emerging targets and combination therapies
HT Marshall, MBA Djamgoz - Frontiers in oncology, 2018 - frontiersin.org
Host immunity recognizes and eliminates most early tumor cells, yet immunological
checkpoints, exemplified by CTLA-4, PD-1, and PD-L1, pose a significant obstacle to …
checkpoints, exemplified by CTLA-4, PD-1, and PD-L1, pose a significant obstacle to …
Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety
Chimeric antigen receptor (CAR) T cell-based immunotherapy, approved by the US Food
and Drug Administration, has shown curative potential in patients with haematological …
and Drug Administration, has shown curative potential in patients with haematological …
Recent progress in upconversion nanomaterials for emerging optical biological applications
H Chen, B Ding, J Lin - Advanced Drug Delivery Reviews, 2022 - Elsevier
The recent advances of upconversion nanoparticles (UCNPs) have made them the ideal
“partner” for a variety of biological applications. In this review, we describe the emerging …
“partner” for a variety of biological applications. In this review, we describe the emerging …
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering
Plant-based photosensors, such as the light-oxygen-voltage sensing domain 2 (LOV2) from
oat phototropin 1, can be modularly wired into cell signaling networks to remotely control …
oat phototropin 1, can be modularly wired into cell signaling networks to remotely control …
Immunotherapy for malignant glioma: current status and future directions
Glioma is the most common intracranial primary malignancy, with limited treatment options
and a poor overall survival (OS). Immunotherapy has been used successfully in various …
and a poor overall survival (OS). Immunotherapy has been used successfully in various …
Near-infrared optogenetic engineering of photothermal nanoCRISPR for programmable genome editing
X Chen, Y Chen, H Xin, T Wan… - Proceedings of the …, 2020 - National Acad Sciences
We herein report an optogenetically activatable CRISPR-Cas9 nanosystem for
programmable genome editing in the second near-infrared (NIR-II) optical window. The …
programmable genome editing in the second near-infrared (NIR-II) optical window. The …
Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy
The cGAS-STING signaling pathway has emerged as a promising target for immunotherapy
development. Here, we introduce a light-sensitive optogenetic device for control of the …
development. Here, we introduce a light-sensitive optogenetic device for control of the …
Optogenetics for transcriptional programming and genetic engineering
Optogenetics combines genetics and biophotonics to enable noninvasive control of
biological processes with high spatiotemporal precision. When engineered into protein …
biological processes with high spatiotemporal precision. When engineered into protein …
Identification and validation of neurotrophic factor-related genes signature in HNSCC to predict survival and immune landscapes
G Peng, H Chi, X Gao, J Zhang, G Song, X Xie… - Frontiers in …, 2022 - frontiersin.org
Background: Head and neck squamous cell carcinoma (HNSCC) is the seventh most
common type of cancer worldwide. Its highly aggressive and heterogeneous nature and …
common type of cancer worldwide. Its highly aggressive and heterogeneous nature and …