In addition to providing increased structural stability to extracellular proteins, the reversible
formation of disulfide bonds is utilized biologically in enzyme catalytic mechanisms, in the …

Mechanisms of flavoproteinâ•’catalyzed reactions Page 1 t < FF’HS 1989 Re view
Mechanisms of flavoprotein-catalyzed reactions Sandro CHISLA‘ and Vincent MASSEY ’ …

Leishmaniasis is a neglected tropical disease that affects about 350 million individuals
worldwide. The protozoan parasite has a relatively simple life cycle with two principal …

Leishmaniasis is a disease that affects 2 million people and kills 70000 persons every year.
It is caused by Leishmania species, which are human protozoan parasites of the …

In Kinetoplastida, trypanothione and trypanothione reductase (TRYR) provide an
intracellular reducing environment, substituting for the glutathione–glutathione reductase …

Parasitic protozoa belonging to the order Kinetoplastida contain trypanothione as their major
thiol. Trypanothione reductase (TR), the enzyme responsible for maintaining trypanothione …

A peroxide reductase (peroxidase) which converts lipid hydroperoxides and other alkyl
hydroperoxides to the corresponding alcohols, using either NADH or NADPH as the …

Over the last few years a remarkable progress has been made in the understanding of
parasites biochemistry, molecular biology, and immunology. This progress is especially …

The pyridine nucleotide-disulfide oxidoreductases form a family of homo-dimeric fla
voenzymes having a redox-active disulfide and a FAD in each monomer. The well …

The trypanosomatid metabolite N1, N8-bis-(glutathionyl) spermidine (trypanothione) has
been demonstrated to form a stable adduct with the aromatic arsenical drug melarsen oxide …