Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …

Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …

Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …

Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains and
rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of …

Clustered somatic mutations are common in cancer genomes and previous analyses reveal
several types of clustered single-base substitutions, which include doublet-and multi-base …

Cytosolic DNA is characteristic of chromosomally unstable metastatic cancer cells, resulting
in constitutive activation of the cGAS–STING innate immune pathway. How tumors co-opt …

Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer
evolution studies, providing insight into the clonality and relative ordering of mutations and …

To increase understanding of the genomic landscape of acral melanoma, a rare form of
melanoma occurring on palms, soles or nail beds, whole genome sequencing of 87 tumors …

Background Cancer genomes are peppered with somatic mutations imprinted by different
mutational processes. The mutational pattern of a cancer genome can be used to identify …

Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …