Primary open-angle glaucoma is a progressive optic neuropathy and, perhaps, the most
common form of glaucoma. Because the disease is treatable, and because the visual …

Diabetic macular edema is a major cause of visual impairment. The pathogenesis of
macular edema appears to be multifactorial. Laser photocoagulation is the standard of care …

The uveoscleral outflow route was described more than 40years ago. Part of aqueous
leaves the eye through the iris root. The ciliary muscle, and there are large species …

A decade has passed since the first topical prostaglandin analog was prescribed to reduce
intraocular pressure (IOP) for the treatment of glaucoma. Now four prostaglandin analogs …

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade
extracellular matrix (ECM) components such as collagen and have important roles in …

Topical treatments with certain prostaglandins (PGs), including FP receptor agonists, lower
intraocular pressure by increasing uveoscleral outflow. Although the precise mechanism for …

This review analyzes the currently available literature on circadian rhythms of intraocular
pressure (IOP), blood pressure, and calculated ocular perfusion pressure (OPP) in patients …

Elevated intraocular pressure (IOP) is the most prevalent risk factor for glaucoma. All
treatments, whether surgical or pharmaceutical, are aimed at lowering IOP. Prostaglandin …

The research that led to the concept of using prostaglandins for reduction of intraocular
pressure (IOP) has been discussed by Bito and goes back to the early 1980s, when it was …

Background Topical prostaglandin F 2α isopropyl ester increases uveoscleral outflow in
monkeys and humans. Objective To investigate the effects of prostaglandin F 2α isopropyl …