Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus,
known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally …

Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

Mitochondria serves a primary role in energy maintenance but also function to govern levels
of mitochondria-derived reactive oxygen species (mROS). ROS have long been established …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

Reductive stress (RS) is the counterpart oxidative stress (OS), and can occur in response to
conditions that shift the redox balance of important biological redox couples, such as the …

This review traces the discoveries that led to the recognition of selenium (Se) as an essential
nutrient and discusses Se-responsive diseases in animals and humans in the context of …

Selenoproteins are proteins containing selenium in the form of the 21st amino acid,
selenocysteine. Members of this protein family have many diverse functions, but their …

Abstract Glutathione peroxidase-1 (GPX1) represents the first identified mammalian
selenoprotein, and our understanding in the metabolic regulation and function of this …

In the last few decades, the importance of selenium in human health has been the subject of
numerous studies. It is believed that the physiological effects of selenium occur mainly …

Knowledge of the plasma selenium levels associated with optimised concentration or activity
of specific selenoproteins can provide considerable insights from epidemiological data on …