Innovative chemical tools to address analytical challenges of protein phosphorylation and glycosylation
M Li, Y Xiong, G Qing - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Protein post-translational modifications (PTMs) modulate almost all cellular
processes. Aberrant PTMs are closely bound to various human diseases, which greatly …
processes. Aberrant PTMs are closely bound to various human diseases, which greatly …
Nanopore: Emerging for detecting protein post-translational modifications
X Zhao, H Qin, M Tang, X Zhang, G Qing - TrAC Trends in Analytical …, 2024 - Elsevier
Protein post-translational modifications (PTMs) play pivotal roles in almost every cellular
process, influencing protein stability, localization, interactions, and enzymatic activities. PTM …
process, influencing protein stability, localization, interactions, and enzymatic activities. PTM …
Direct identification of complex glycans via a highly sensitive engineered nanopore
G Yao, Y Tian, W Ke, J Fang, S Ma, T Li… - Journal of the …, 2024 - ACS Publications
The crucial roles that glycans play in biological systems are determined by their structures.
However, the analysis of glycan structures still has numerous bottlenecks due to their …
However, the analysis of glycan structures still has numerous bottlenecks due to their …
Enrichment driven glycoproteomics: New materials, new methods, and beyond
Y Xiong, M Li, Y Liu, X Liang, G Qing - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Glycoproteomics is a rapidly growing field that aims to identify and characterize protein
glycosylation events at a system level. However, the analysis of protein glycosylation in …
glycosylation events at a system level. However, the analysis of protein glycosylation in …
Sensing PEGylated Peptide Conformations Using a Protein Nanopore
Membrane pores are exploited for the stochastic sensing of various analytes, and here, we
use electrical recordings to explore the interaction of PEGylated peptides of different sizes …
use electrical recordings to explore the interaction of PEGylated peptides of different sizes …
Towards chemoenzymatic labeling strategies for profiling protein glycosylation
Y Tian, S Ma, L Wen - Current Opinion in Chemical Biology, 2024 - Elsevier
Protein glycosylation is one of the most common and important post-translational
modifications of proteins involved in regulating glycoprotein functions. The chemoenzymatic …
modifications of proteins involved in regulating glycoprotein functions. The chemoenzymatic …
Precise Capture and Dynamic Release of Circulating Liver Cancer Cells with Dual‐Histidine‐Based Cell Imprinted Hydrogels
W Sun, X You, X Zhao, X Zhang, C Yang… - Advanced …, 2024 - Wiley Online Library
Circulating tumor cells (CTCs) detection presents significant advantages in diagnosing liver
cancer due to its noninvasiveness, real‐time monitoring, and dynamic tracking. However …
cancer due to its noninvasiveness, real‐time monitoring, and dynamic tracking. However …
[HTML][HTML] Sensitive and specific detection of saccharide species based on fluorescence: update from 2016
X Huang, Y Han, J Li, M Tang, G Qing - Analytical and Bioanalytical …, 2023 - Springer
Increasing evidence supports the critical role of saccharides in various pathophysiological
steps of tumor progression, where they regulate tumor proliferation, invasion, hematogenic …
steps of tumor progression, where they regulate tumor proliferation, invasion, hematogenic …
Recent advances of nanopore-based analysis for carbohydrate and glycoconjugate
Saccharides are not only the basic constituents and nutrients of living organisms, but also
participate in various life activities, and play important roles in cell recognition, immune …
participate in various life activities, and play important roles in cell recognition, immune …
Precise Structural Analysis of Neutral Glycans Using Aerolysin Mutant T240R Nanopore
W Lu, X Zhao, M Li, Y Li, C Zhang, Y Xiong, J Li… - ACS …, 2024 - ACS Publications
Glycans play vital roles in nearly all life processes of multicellular organisms, and
understanding these activities is inseparable from elucidating the biological significance of …
understanding these activities is inseparable from elucidating the biological significance of …