Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic
acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor …

In recent years, it has become clear that the current standard therapeutic options for
pancreatic cancer are not adequate and still do not meet the criteria to cure patients …

Midkine (MK) is a heparin-binding cytokine, and promotes growth, survival, migration and
other activities of target cells. After describing the general properties of MK, this review …

Object Malignant brain tumors have been proved to be resistant to standard treatments and
therefore require new therapeutic strategies. Survivin, a recently described member of the …

Midkine (MDK) expression is associated with the proliferation of many cancers, including
glioma. However, the upstream signaling that leads to MDK accumulation remains elusive …

Oncolytic virotherapy has recently emerged as a promising strategy for inducing tumor-
specific cell death. Adenoviruses are widely and frequently used in oncolytic virotherapy …

Adenovirus serotype 5 (Ad5) is widely and frequently used as a virus vector in cancer gene
therapy and oncolytic virotherapy. Oncolytic virotherapy is a novel antitumor treatment for …

Midkine (MDK) is a neurotrophic growth factor highly expressed during embryogenesis with
important functions related to growth, proliferation, survival, migration, angiogenesis …

Since diagnosis at an early stage still remains a key issue for modern oncology and is
crucial for successful cancer therapy, development of sensitive, specific, and non-invasive …

Cancer stem cells (CSC) are a very small subset of all cancer cells and possess
characteristics very similar to normal stem cells, in particular, the capacity for self-renewal …