Sex differences in the epilepsies and associated comorbidities: implications for use and development of pharmacotherapies

CA Christian, DS Reddy, J Maguire, PA Forcelli… - Pharmacological …, 2020 - Elsevier
The epilepsies are common neurologic disorders characterized by spontaneous recurrent
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …

Mechanisms linking neurological disorders with reproductive endocrine dysfunction: insights from epilepsy research

CA Cutia, CA Christian-Hinman - Frontiers in Neuroendocrinology, 2023 - Elsevier
Gonadal hormone actions in the brain can both worsen and alleviate symptoms of
neurological disorders. Although neurological conditions and reproductive endocrine …

Sex-specific disease modifiers in juvenile myoclonic epilepsy

A Shakeshaft, N Panjwani, A Collingwood… - Scientific reports, 2022 - nature.com
Juvenile myoclonic epilepsy (JME) is a common idiopathic generalised epilepsy with
variable seizure prognosis and sex differences in disease presentation. Here, we investigate …

Hormones and sex-specific medicine in human physiopathology

MR Tokatli, LG Sisti, E Marziali, L Nachira, MF Rossi… - Biomolecules, 2022 - mdpi.com
A prodigious increment of scientific evidence in both preclinical and clinical studies is
narrowing a major gap in knowledge regarding sex-specific biological responses observed …

Protective effects of intranasally administrated oxytocin-loaded nanoparticles on pentylenetetrazole-kindling epilepsy in terms of seizure severity, memory …

H Sahin, O Yucel, S Emik… - ACS Chemical …, 2022 - ACS Publications
Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal
lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and …

Alterations in salivary biochemical composition and redox state disruption induced by the anticonvulsant valproic acid in male rat salivary glands

RN de Freitas, LGL da Silva, GA Fiais… - Archives of Oral …, 2023 - Elsevier
Objective To investigate the effects of the anticonvulsant valproic acid (VPA) on salivary
glands in male rat using biochemical, functional, histomorphometric, and redox state …

Differences in evolution of epileptic seizures and topographical distribution of tissue damage in selected limbic structures between male and female rats submitted to …

D Matovu, EA Cavalheiro - Frontiers in Neurology, 2022 - frontiersin.org
Epidemiological evidence shows that clinical features and comorbidities in temporal lobe
epilepsy (TLE) may have different manifestations depending on the sex of patients …

Health related quality of life in a Saudi population of patients with epilepsy

A Eskandrani, E Almusallam, A Alenizi, S Asiri… - Neurosciences …, 2023 - nsj.org.sa
Objectives: To assess the quality of life for epilepsy patients in Saudi Arabia. Epilepsy, one
of the most prevalent chronic neurological conditions in the world, frequently results in a low …

Sex‐specific differences in mortality and neurocardiac interactions in the Kv1. 1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP)

K Paulhus, P Kumar, K Kneale… - The Journal of …, 2025 - Wiley Online Library
Sudden unexpected death in epilepsy (SUDEP) is a devastating complication of epilepsy
with possible sex‐specific risk factors, although the exact relationship between sex and …

Considering social determinants of health in the relationship between physical activity and exercise engagement and cognitive impairment among persons with …

B Hansen, JB Allendorfer - Frontiers in Rehabilitation Sciences, 2022 - frontiersin.org
Many persons with epilepsy (PWE) are not as active or physically fit as compared to the
general population. This lack of engagement in physical activity has been attributed to a …