Radiologically suspected low-grade gliomas (LGG) represent a special challenge for the
neurosurgeon during surgery due to their histopathological heterogeneity and indefinite …

Solid-state single photon detectors are playing a significant role in the development of high-
performance single-photon imaging systems for fluorescence lifetime imaging, time-of-flight …

Current clinical brain imaging techniques used for surgical planning of tumor resection lack
intraoperative and real‐time feedback; hence surgeons ultimately rely on subjective …

Organisms belonging to all life kingdoms may have the natural capacity to fluoresce.
Autofluorescence events depend on the presence of natural biomolecules, namely …

Intravital fluorescence microscopy enables the direct imaging of fluorophores in vivo and
advanced techniques such as fluorescence lifetime imaging (FLIM) enable the simultaneous …

Fluorescence lifetime is not only associated with the molecular structure of fluorophores, but
also strongly depends on the environment around them, which allows fluorescence lifetime …

Fiber based fluorescence lifetime imaging has shown great potential for intraoperative
diagnosis and guidance of surgical procedures. Here we describe a novel method …

Maximal safe resection is a key strategy for improving patient prognosis in the management
of brain tumors. Intraoperative fluorescence guidance has emerged as a standard in the …

Achieving a maximal safe extent of resection during brain tumor surgery is the goal for
improved patient prognosis. Fluorescence‐guided neurosurgery using 5‐aminolevulinic …

Two photon fluorescence microscopy and the numerous technical advances to it have
served as valuable tools in biomedical research. The fluorophores (exogenous or …