The inhibitory neurotransmitter GABA acts in the mammalian brain through two different
receptor classes: GABAA and GABAB receptors. GABAB receptors differ fundamentally from …

Hyperpolarization‐activated cation currents (Ih) contribute to various physiological
properties and functions in the brain, including neuronal pacemaker activity, setting of …

Receptor-specific compounds were applied by retrograde microdialysis to the ventral
tegmental area (VTA) of the rat brain. The effect of the intrategmental infusions on …

Rhythmic firing in brain and heart is mediated by pacemaker channels that are activated by
hyperpolarization and regulated directly by cyclic nucleotides. Recent work has identified a …

Ethanol stimulates the firing activity of midbrain dopamine (DA) neurons, leading to
enhanced dopaminergic transmission in the mesolimbic system. This effect is thought to …

abstract Intracellular electrophysiological recordings in current‐and voltage‐clamp mode
were obtained from dopaminergic neurons of the rat mesencephalon in an in vitro slice …

Parkinson's disease (PD) involves progressive loss of nigrostriatal dopamine (DA) neurons
over an extended period of time. Mitochondrial damage may lead to PD, and neurotoxins …

Orphanin FQ has been reported to suppress extracellular dopamine levels in the nucleus
accumbens after intracerebroventricular administration. This study sought to provide …

Intracellular recordings were made with conventional microelectrodes and with whole-cell
patch-clamp electrodes from neurons of the rat ventral tegmental area and substantia nigra …

Stimulation of α2‐noradrenergic (NA) receptors within the PFC improves working memory
performance. This improvement is accompanied by a selective increase in the activity of …