Fibrosis—a common pathway to organ injury and failure
DC Rockey, PD Bell, JA Hill - New England Journal of Medicine, 2015 - Mass Medical Soc
Fibrosis — A Common Pathway to Organ Injury and Failure | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …
Skip to main content The New England Journal of Medicine homepage Advanced Search …
Liver fibrosis and repair: immune regulation of wound healing in a solid organ
A Pellicoro, P Ramachandran, JP Iredale… - Nature Reviews …, 2014 - nature.com
Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …
[PDF][PDF] Hepatic stellate cells and liver fibrosis
JE Puche, Y Saiman, SL Friedman - Compr Physiol, 2013 - academia.edu
Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …
remarkable range of functions in normal and injured liver. Derived embryologically from …
[HTML][HTML] Kupffer cells in the liver
LJ Dixon, M Barnes, H Tang, MT Pritchard… - Comprehensive …, 2013 - ncbi.nlm.nih.gov
Kupffer cells are a critical component of the mononuclear phagocytic system and are central
to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as …
to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as …
Adverse outcome pathways: opportunities, limitations and open questions
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …
formalized, transparent and quality-controlled way, mechanistic information to apical …
Novel insights into the function and dynamics of extracellular matrix in liver fibrosis
MA Karsdal, T Manon-Jensen… - American Journal …, 2015 - journals.physiology.org
Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …
Dopamine receptor D2 antagonism normalizes profibrotic macrophage-endothelial crosstalk in non-alcoholic steatohepatitis
J Qing, Y Ren, Y Zhang, M Yan, H Zhang, D Wu… - Journal of …, 2022 - Elsevier
Background & Aims Currently there is no effective treatment for liver fibrosis, which is one of
the main histological determinants of non-alcoholic steatohepatitis (NASH). While …
the main histological determinants of non-alcoholic steatohepatitis (NASH). While …
Exosomal miR‐103‐3p from LPS‐activated THP‐1 macrophage contributes to the activation of hepatic stellate cells
L Chen, X Yao, H Yao, Q Ji, G Ding, X Liu - The FASEB Journal, 2020 - Wiley Online Library
Hepatic fibrosis occurs during chronic hepatic injury and is involved in hepatic stellate cells
(HSCs) activated by several types of immune cells. Among the immune cells, hepatic …
(HSCs) activated by several types of immune cells. Among the immune cells, hepatic …
Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology
In hepatic schistosomiasis, pathology arises when schistosome eggs become lodged in the
host liver, evoking an interleukin 4 (IL-4)-and IL-13-mediated dominant CD4+ Th2 immune …
host liver, evoking an interleukin 4 (IL-4)-and IL-13-mediated dominant CD4+ Th2 immune …
Advanced glycation end-products as mediators of the aberrant crosslinking of extracellular matrix in scarred liver tissue
The extracellular matrix of cirrhotic liver tissue is highly crosslinked. Here we show that
advanced glycation end-products (AGEs) mediate crosslinking in liver extracellular matrix …
advanced glycation end-products (AGEs) mediate crosslinking in liver extracellular matrix …