Fibrosis—a common pathway to organ injury and failure

DC Rockey, PD Bell, JA Hill - New England Journal of Medicine, 2015 - Mass Medical Soc
Fibrosis — A Common Pathway to Organ Injury and Failure | New England Journal of Medicine
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Liver fibrosis and repair: immune regulation of wound healing in a solid organ

A Pellicoro, P Ramachandran, JP Iredale… - Nature Reviews …, 2014 - nature.com
Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …

[PDF][PDF] Hepatic stellate cells and liver fibrosis

JE Puche, Y Saiman, SL Friedman - Compr Physiol, 2013 - academia.edu
Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

[HTML][HTML] Kupffer cells in the liver

LJ Dixon, M Barnes, H Tang, MT Pritchard… - Comprehensive …, 2013 - ncbi.nlm.nih.gov
Kupffer cells are a critical component of the mononuclear phagocytic system and are central
to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as …

Adverse outcome pathways: opportunities, limitations and open questions

M Leist, A Ghallab, R Graepel, R Marchan… - Archives of …, 2017 - Springer
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

Novel insights into the function and dynamics of extracellular matrix in liver fibrosis

MA Karsdal, T Manon-Jensen… - American Journal …, 2015 - journals.physiology.org
Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Dopamine receptor D2 antagonism normalizes profibrotic macrophage-endothelial crosstalk in non-alcoholic steatohepatitis

J Qing, Y Ren, Y Zhang, M Yan, H Zhang, D Wu… - Journal of …, 2022 - Elsevier
Background & Aims Currently there is no effective treatment for liver fibrosis, which is one of
the main histological determinants of non-alcoholic steatohepatitis (NASH). While …

Exosomal miR‐103‐3p from LPS‐activated THP‐1 macrophage contributes to the activation of hepatic stellate cells

L Chen, X Yao, H Yao, Q Ji, G Ding, X Liu - The FASEB Journal, 2020 - Wiley Online Library
Hepatic fibrosis occurs during chronic hepatic injury and is involved in hepatic stellate cells
(HSCs) activated by several types of immune cells. Among the immune cells, hepatic …

Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology

C Chuah, MK Jones, ML Burke, DP McManus… - Trends in …, 2014 - cell.com
In hepatic schistosomiasis, pathology arises when schistosome eggs become lodged in the
host liver, evoking an interleukin 4 (IL-4)-and IL-13-mediated dominant CD4+ Th2 immune …

Advanced glycation end-products as mediators of the aberrant crosslinking of extracellular matrix in scarred liver tissue

C Lyu, W Kong, Z Liu, S Wang, P Zhao… - Nature biomedical …, 2023 - nature.com
The extracellular matrix of cirrhotic liver tissue is highly crosslinked. Here we show that
advanced glycation end-products (AGEs) mediate crosslinking in liver extracellular matrix …