Approximately 30-40% of patients with well-differentiated neuroendocrine tumors present
with carcinoid syndrome, which is a paraneoplastic syndrome associated with the secretion …

Objective This systematic review and meta-analysis aimed to develop an evidence-based
summary of current knowledge of bone metastases (BMs) in neuroendocrine neoplasms …

Background Hyperactivation of mTOR pathway and angiogenesis have been implicated in
the pathogenesis of neuroendocrine tumors (NETs). Everolimus, an oral inhibitor of mTOR …

The background to this study was that factors associated with carcinoid heart disease (CHD)
and its impacts on overall survival (OS) are scantly investigated in patients (pts) with …

Purpose As of 2020, the world is facing the great challenge of the COVID-19 (Coronavirus
disease 2019) pandemic, caused by the SARS-CoV-2 virus. While the overall mortality is …

Abstract Introduction Soft tissue sarcomas (STSs) are rare tumors and constitute only 1% of
all tumors in adults. Indeed, due to their rarity, most cases in Brazil are not treated according …

Pancreatic neuroendocrine neoplasms (PNENs) are relatively rare with a reported incidence
of 1–2/100,000 and generally thought to originate from the precursor of the neuroendocrine …

Background Most guidelines still recommend active surveillance for patients with
asymptomatic, unresectable neuroendocrine tumors (NETs). However, recent findings from …

Background Preclinical studies have suggested that metformin has anti-tumour effects, likely
due to blockage of mammalian target of rapamycin pathway through adenosine …

With population growth, increasing risk factor exposure, and the advancing age of the
population, cancer cases and cancer deaths will continue to increase. There are currently …