Purpose of review Over the past 3 decades, Ilizarov technique namely distraction
histogenesis (DH) technique has been widely accepted and applied in orthopaedics and …

Distraction osteogenesis (DO) is a mechanobiological process of regenerating bone tissue
by tension stress. DO is used clinically to lengthen bones or to treat critical size bone …

Bone regeneration represents still a challenge, in particular for calvarium defects. Recently,
the development of biomaterials with the addiction of stem cells is giving promising results …

Objectives High glucose (HG)–mediated bone marrow mesenchymal stem cell (BMSC)
dysfunction plays a key role in impaired bone formation induced by type 1 diabetes mellitus …

Distraction osteogenesis (DO) is a powerful method to reconstruct segmented bone defects
in the extremities. However, the main shortcoming of DO is the time-consuming …

Background: The concept of reverse dynamization involves modifying the mechanical
environment surrounding a fracture to influence the healing response. Initially, less rigid …

Distraction osteogenesis has widespread clinical use in the treatment of large bone defects.
Nonetheless, the prolonged consolidation period carries the risk of complications …

Distraction osteogenesis (DO) is a kind of bone regeneration technology. The principle is to
incise the cortical bone and apply continuous and stable distraction force to the fractured …

Background Hypoxia is the critical driving force for angiogenesis and can trigger the
osteogenic-angiogenic coupling followed by the enhancement of bone regeneration. While …

Background: Interfragmentary movements have benefits in the improvement of bone
formation during distraction osteogenesis (DO). Although several clinical studies reported …