Mechanics of 3D cell–hydrogel interactions: experiments, models, and mechanisms
Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …
Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …
between the biophysical tumor microenvironment and genetic regulation has significant …
Linking cell mechanical memory and cancer metastasis
E Cambria, MF Coughlin, MA Floryan… - Nature Reviews …, 2024 - nature.com
Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …
is limited by incomplete understanding of the biological mechanisms that drive metastasis …
[HTML][HTML] Broad targeting of angiogenesis for cancer prevention and therapy
Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …
is a main driving force in many severe human diseases including cancer. As such, tumor …
Microfluidic modelling of the tumor microenvironment for anti-cancer drug development
Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …
Mechanical compression drives cancer cells toward invasive phenotype
JM Tse, G Cheng, JA Tyrrell… - Proceedings of the …, 2012 - National Acad Sciences
Uncontrolled growth in a confined space generates mechanical compressive stress within
tumors, but little is known about how such stress affects tumor cell behavior. Here we show …
tumors, but little is known about how such stress affects tumor cell behavior. Here we show …
Interstitial flow influences direction of tumor cell migration through competing mechanisms
WJ Polacheck, JL Charest… - Proceedings of the …, 2011 - National Acad Sciences
Interstitial flow is the convective transport of fluid through tissue extracellular matrix. This
creeping fluid flow has been shown to affect the morphology and migration of cells such as …
creeping fluid flow has been shown to affect the morphology and migration of cells such as …
Chemoresistance and the self-maintaining tumor microenvironment
G Yeldag, A Rice, A del Río Hernández - Cancers, 2018 - mdpi.com
The progression of cancer is associated with alterations in the tumor microenvironment,
including changes in extracellular matrix (ECM) composition, matrix rigidity …
including changes in extracellular matrix (ECM) composition, matrix rigidity …
Tumor microenvironment targeted nanotherapy
C Fernandes, D Suares, MC Yergeri - Frontiers in pharmacology, 2018 - frontiersin.org
Recent developments in nanotechnology have brought new approaches to cancer
diagnosis and therapy. While enhanced permeability and retention effect promotes nano …
diagnosis and therapy. While enhanced permeability and retention effect promotes nano …
Mechanotransduction of fluid stresses governs 3D cell migration
WJ Polacheck, AE German… - Proceedings of the …, 2014 - National Acad Sciences
Solid tumors are characterized by high interstitial fluid pressure, which drives fluid efflux from
the tumor core. Tumor-associated interstitial flow (IF) at a rate of∼ 3 µm/s has been shown to …
the tumor core. Tumor-associated interstitial flow (IF) at a rate of∼ 3 µm/s has been shown to …