Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Nociception is the process of transmission of painful signals by nociceptors in the primary
afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are …

Spirulina platensis is a “super-food” and has attracted researchers' attention due to its anti-
inflammatory, antioxidant, and analgesic properties. Herein, we investigated the …

Transient receptor potential (TRP) ion channels are emerging as a new set of membrane
proteins involved in a vast array of cellular processes and regulated by a large number of …

It is now well established that antibodies have numerous potential benefits when developed
as therapeutics. Here, we evaluate the technical challenges of raising antibodies to …

ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential
(TRP) channels that are activated by changes in the environmental temperature, from …

The transient receptor potential (TRP) family comprises a diverse group of cation channels
that regulate a variety of intracellular signaling pathways. The TRPV1 (vanilloid 1) channel is …

A-kinase anchoring proteins (AKAPs) streamline signal transduction by localizing signaling
enzymes with their substrates. Great strides have been made in elucidating the role of these …

TRPM8 is a cold sensor that is highly expressed in the prostate as well as in other non-
temperature-sensing organs, and is regulated by downstream receptor–activated signaling …

Cloning of the transient receptor potential vanilloid type 1 (TRPV1), the heat-gated cation
channel/capsaicin receptor expressed by sensory neurons, has opened the door for …