Melatonin's therapeutic potential has been highly underestimated because its biological
functional roles are diverse and relevant mechanisms are complicated. Among the …

Bone defects are primarily the result of high-energy trauma, pathological fractures, bone
tumor resection, or infection debridement. The treatment of bone defects remains a huge …

Accumulating studies have shown that oxidative stress increases with aging, which is
related to the pathophysiology of postmenopausal osteoporosis. Pyrroloquinoline quinone …

Therapeutic strategies designed to inhibit the activation of microglia may lead to significant
advancement in the treatment of most neurodegenerative diseases. Pyrroloquinoline …

Psoralidin is a metabolic product from the seed of psoraleacorylifolia, possessed anti-
inflammatory and immunomodulatory effects. We speculated that psoralidin might impact …

Age‐related osteoporosis is associated with increased oxidative stress and cellular
senescence. Pyrroloquinoline quinone (PQQ) is a water‐soluble vitamin‐like compound that …

Pyrroloquinoline quinone (PQQ) is a naturally occurring redox cofactor that acts as an
essential nutrient and antioxidant and has been reported to exert potent immunosuppressive …

Background/Aims: Osteoporosis is a metabolic bone disorder that tortures about millions of
people worldwide. Recent study demonstrated agents derived from picrasma quassioides is …

Although studies have established the role of integrins in bone homeostasis, especially in
osteoclastogenesis, and these molecules are novel and promising therapeutic drug targets …

Aseptic loosening secondary to periprosthetic inflammatory osteolysis results from the
biological response to wear particles and is a leading cause of arthroplasty failure. The …