Modern anti-tuberculosis drugs and their classification. Part I: first-line drugs
LA Kayukova, EA Berikova - Pharmaceutical Chemistry Journal, 2020 - Springer
The historical classification (1993) of anti-tuberculosis drugs included three (I-III) lines that
were subdivided into five groups (2006). The duration of treatment of drug-sensitive (DS) …
were subdivided into five groups (2006). The duration of treatment of drug-sensitive (DS) …
Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies
TB continues to be a leading health threat despite the availability of powerful anti-TB drugs.
We report herein the design and synthesis of various hybrid molecules comprising pyrazine …
We report herein the design and synthesis of various hybrid molecules comprising pyrazine …
Design, synthesis and biological evaluation of substituted 3-amino-N-(thiazol-2-yl) pyrazine-2-carboxamides as inhibitors of mycobacterial methionine …
M Juhás, VSK Pallabothula, K Grabrijan… - Bioorganic …, 2022 - Elsevier
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is the number one cause of
deaths due to a single infectious agent worldwide. The treatment of TB is lengthy and often …
deaths due to a single infectious agent worldwide. The treatment of TB is lengthy and often …
[HTML][HTML] Adenosine-mimicking derivatives of 3-aminopyrazine-2-carboxamide: Towards inhibitors of prolyl-tRNA synthetase with antimycobacterial activity
VSK Pallabothula, M Kerda, M Juhás, O Janďourek… - Biomolecules, 2022 - mdpi.com
Multidrug-resistant tuberculosis (MDR-TB) poses a significant threat to mankind and as such
earned its place on the WHO list of priority pathogens. New antimycobacterials with a …
earned its place on the WHO list of priority pathogens. New antimycobacterials with a …
[HTML][HTML] Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies
L Pang, SD Weeks, M Juhás, SV Strelkov… - International Journal of …, 2021 - mdpi.com
Human cytosolic prolyl-tRNA synthetase (HcProRS) catalyses the formation of the prolyl-
tRNAPro, playing an important role in protein synthesis. Inhibition of HcProRS activity has …
tRNAPro, playing an important role in protein synthesis. Inhibition of HcProRS activity has …
Anti-tubercular activity of pyrazinamide conjugates: synthesis and structure-activity relationship studies
SK Wahan, S Sharma… - Mini Reviews in Medicinal …, 2023 - ingentaconnect.com
Tuberculosis (TB) is an airborne infection caused by the bacteria Mycobacterium
Tuberculosis (MTB). It mainly affects the lungs and causes severe coughing, fever, and chest …
Tuberculosis (MTB). It mainly affects the lungs and causes severe coughing, fever, and chest …
[HTML][HTML] Ureidopyrazine derivatives: Synthesis and biological evaluation as anti-infectives and abiotic elicitors
G Bouz, M Juhás, P Niklová, O Janďourek, P Paterová… - Molecules, 2017 - mdpi.com
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) has become a frequently
deadly infection due to increasing antimicrobial resistance. This serious issue has driven …
deadly infection due to increasing antimicrobial resistance. This serious issue has driven …
Synthesis and antimycobacterial evaluation of pyrazinamide, benzimidazole and carboxamide derivatives
Due to the unusual structure and chemical composition of the mycobacterial cell wall, it is
difficult to develop effective antitubercular treatment as it leads to many antibiotics not …
difficult to develop effective antitubercular treatment as it leads to many antibiotics not …
[HTML][HTML] Low-molecular pyrazine-based DNA binders: Physicochemical and antimicrobial properties
Pyrazine and its derivatives are a large group of compounds that exhibit broad biological
activity, the changes of which can be easily detected by a substituent effect or a change in …
activity, the changes of which can be easily detected by a substituent effect or a change in …