The structural biology of HIV-1: mechanistic and therapeutic insights
A Engelman, P Cherepanov - Nature Reviews Microbiology, 2012 - nature.com
Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …
mechanisms and, for cases in which the molecular function affects human health, can …
Neutralization of virus infectivity by antibodies: old problems in new perspectives
PJ Klasse - Advances in biology, 2014 - Wiley Online Library
Neutralizing antibodies (NAbs) can be both sufficient and necessary for protection against
viral infections, although they sometimes act in concert with cellular immunity. Successful …
viral infections, although they sometimes act in concert with cellular immunity. Successful …
Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans
New broad and potent neutralizing HIV-1 antibodies have recently been described that are
largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 …
largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 …
Increasing the potency and breadth of an HIV antibody by using structure-based rational design
R Diskin, JF Scheid, PM Marcovecchio, AP West Jr… - Science, 2011 - science.org
Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can
show exceptional potency and breadth. We determined structures of NIH45-46, a more …
show exceptional potency and breadth. We determined structures of NIH45-46, a more …
Avoiding drug resistance in HIV reverse transcriptase
ME Cilento, KA Kirby, SG Sarafianos - Chemical reviews, 2021 - ACS Publications
HIV reverse transcriptase (RT) is an enzyme that plays a major role in the replication cycle of
HIV and has been a key target of anti-HIV drug development efforts. Because of the high …
HIV and has been a key target of anti-HIV drug development efforts. Because of the high …
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops
YD Kwon, A Finzi, X Wu… - Proceedings of the …, 2012 - National Acad Sciences
The HIV-1 envelope (Env) spike (gp1203/gp413) undergoes considerable structural
rearrangements to mediate virus entry into cells and to evade the host immune response …
rearrangements to mediate virus entry into cells and to evade the host immune response …
Molecular mechanism of respiratory syncytial virus fusion inhibitors
MB Battles, JP Langedijk… - Nature chemical …, 2016 - nature.com
Respiratory syncytial virus (RSV) is a leading cause of pneumonia and bronchiolitis in
young children and the elderly. Therapeutic small molecules have been developed that bind …
young children and the elderly. Therapeutic small molecules have been developed that bind …
Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions
The entry of human immunodeficiency virus (HIV-1) into cells is initiated by binding of the
gp120 exterior envelope glycoprotein to the receptor, CD4. How does CD4 binding trigger …
gp120 exterior envelope glycoprotein to the receptor, CD4. How does CD4 binding trigger …
CD4 mimetics sensitize HIV-1-infected cells to ADCC
J Richard, M Veillette, N Brassard… - Proceedings of the …, 2015 - National Acad Sciences
HIV-1-infected cells presenting envelope glycoproteins (Env) in the CD4-bound
conformation on their surface are preferentially targeted by antibody-dependent cell …
conformation on their surface are preferentially targeted by antibody-dependent cell …
Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529
Abstract The HIV-1 envelope (Env) spike is a conformational machine that transitions
between prefusion (closed, CD4-and CCR5-bound) and postfusion states to facilitate HIV-1 …
between prefusion (closed, CD4-and CCR5-bound) and postfusion states to facilitate HIV-1 …