Genetically engineered mouse models are commonly preferred for studying the human
disease due to genetic and pathophysiological similarities between mice and humans. In …

Considerable progress has been made in understanding the roles of Sox2 and Oct4 in
embryonic stem cells and mammalian embryogenesis. Specifically, significant progress has …

The N 6-methyladenosine (m6A) modification is the most prevalent internal RNA
modification in eukaryotes. The majority of m6A sites are found in the last exon and 3'UTRs …

Size control is fundamental in tissue development and homeostasis,. Although the role of
cell proliferation in these processes has been widely studied, the mechanisms that control …

YTHDF2 binds and destabilizes N 6-methyladenosine (m 6 A)-modified mRNA. The extent to
which this branch of m 6 A RNA-regulatory pathway functions in vivo and contributes to …

Parental epigenomes are established during gametogenesis. While they are largely reset
after fertilization, broad domains of Polycomb repressive complex 2 (PRC2)-mediated …

Inflammasome activation plays a central role in the development of drug‐induced and
obesity‐associated liver disease. However, the sources and mechanisms of inflammasome …

Postnatal growth of mammalian oocytes is accompanied by a progressive gain of DNA
methylation, which is predominantly mediated by DNMT3A, a de novo DNA …

During pre-implantation development, the mammalian embryo self-organizes into the
blastocyst, which consists of an epithelial layer encapsulating the inner-cell mass (ICM) …

De novo DNA methylation (DNAme) in mammalian germ cells is dependent on DNMT3A
and DNMT3L. However, oocytes and spermatozoa show distinct patterns of DNAme. In …