Background Healthcare-associated infections involving Gram-negative bacteria (GNB) with
difficult-to-treat resistance (DTR) phenotype are associated with impaired patient-centered …

Bacterial central nervous system (CNS) infections are serious and carry significant morbidity
and mortality. They encompass many syndromes, the most common being meningitis, which …

Critically ill patients admitted to intensive care unit (ICU) with severe infections, or those who
develop nosocomial infections, have poor outcomes with substantial morbidity and mortality …

Abstract Background Pharmacokinetic/pharmacodynamic (PK/PD) indices are widely used
for the selection of optimum antibiotic doses. For β-lactam antibiotics, fT> MIC, best relates …

Nosocomial central nervous system (CNS) infections with carbapenem-and colistin-resistant
Gram-negative and vancomycin-resistant Gram-positive bacteria are an increasing …

Introduction Ceftolozane is a cephalosporin similar to ceftazidime in its structure, which is
marketed in combination with tazobactam, a well-known β-lactamase inhibitor. Areas …

Clinicians should obtain the bacterial minimum inhibitory concentration when treating
patients with CNS Gram-negative bacterial infections and consider the underlying PK/PD …

Antimicrobial resistance continues to surmount increasing concern globally, and treatment of
difficult‐to‐treat (DTR) Pseudomonas aeruginosa, carbapenem‐resistant (CR) …

Beta-lactam antibiotics are often the backbone of treatment for Gram-negative infections in
the critically ill. Beta-lactams exhibit time-dependent killing, and their efficacy depends on …

We report a case of multidrug-resistant Pseudomonas aeruginosa meningitis treated with
ceftolozane-tazobactam with concomitant therapeutic drug monitoring of plasma and …