Gene expression analyses of bulk tissues often ignore cell type composition as an important
confounding factor, resulting in a loss of signal from lowly abundant cell types. In this review …

Genomics has the potential to revolutionize the diagnosis and management of cancer by
offering an unprecedented comprehensive view of the molecular underpinnings of …

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year survival
rate of 4%. A key hallmark of PDAC is extensive stromal involvement, which makes …

Acute myeloid leukemia (AML) manifests as phenotypically and functionally diverse cells,
often within the same patient. Intratumor phenotypic and functional heterogeneity have been …

Identifying the earliest somatic changes in prostate cancer can give important insights into
tumor evolution and aids in stratifying high-from low-risk disease. We integrated whole …

Despite efforts to profile prostate cancer, the genetic alterations and biological processes
that correlate with the observed histological progression are unclear. Using laser-capture …

We describe cell type–specific significance analysis of microarrays (csSAM) for analyzing
differential gene expression for each cell type in a biological sample from microarray data …

Activation in transformed cells of normal stem cells' self-renewal pathways might contribute
to the survival life cycle of cancer stem cells and promote tumor progression. The BMI-1 …

Background This study was to explore the infiltration pattern of immune cells in the prostate
cancer (PCa) microenvironment and evaluate the possibility of specific infiltrating immune …

Background Prostate cancer is characterized by heterogeneity in the clinical course that
often does not correlate with morphologic features of the tumor. Metastasis reflects the most …