Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …

Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic …

Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25%
one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial …

Induction of cell death is inexorably linked with cancer therapy, but this can also initiate
wound-healing processes that have been linked to cancer progression and therapeutic …

Necroptosis, a form of regulated necrosis, participates in tumor development and dying cell
immunogenicity. However, it remains unclear how tumor cell–intrinsic necroptotic signaling …

Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …

At odds with conventional chemotherapeutics, targeted anticancer agents are designed to
inhibit precise molecular alterations that support oncogenesis or tumor progression. Despite …

Autophagy supports both cellular and organismal homeostasis. However, whether
autophagy should be inhibited or activated for cancer therapy remains unclear. Deletion of …

Summary Cyclic GMP-AMP synthase (cGAS) is the major sensor for cytosolic DNA and
activates type I interferon signaling and plays an essential role in antitumor immunity …