Current therapies for human parasite infections rely on a few drugs, most of which have
severe side effects, and their helpfulness is being seriously compromised by the drug …

Histone deacetylase inhibitors (HDACIs) have a paramount importance in the acetylation
process of histone and non-histone proteins that are crucial players in the cellular epigenetic …

The redirectioning of drugs in the pharmaceutical market is a well-known practice to identify
new therapies for parasitic diseases. The histone deacetylase inhibitors Tubastatin A (TST) …

Chagas disease, caused by Trypanosoma cruzi, still affects millions of people around the
world. No vaccines nor treatment for chronic Chagas disease are available, and …

Histone deacetylases (HDACs) are promising epigenetic targets for the treatment of various
diseases, including cancer and neurodegenerative disorders. There is evidence that they …

Intracellular parasites have evolved intricate strategies to subvert host cell functions for their
own survival. These strategies are particularly damaging to the host if the infection involves …

Recent studies have highlighted a key role in regulating gene transcription, in both
eukaryotes and prokaryotes, by enzymes that control the acetylation and deacetylation of …

There is currently no satisfactory treatment for visceral leishmaniasis; the disease is thus in
desperate need of novel drugs. The ideal candidate should be effective, safe, affordable …

Four diterpenes with biological activity were isolated from Salvia deserta roots. Taxodione
was considered leishmanicidal with an IC 50 value of 1.46 µM (0.46 mg/L) against …

Parasitic protozoa comprise several species that are causative agents of important diseases.
These diseases are distributed throughout the world and include leishmaniasis, Chagas …