Stem cell therapy has shown great efficacy in many diseases. However, the treatment
mechanism is still unclear, which is a big obstacle for promoting clinical research. Therefore …

Not many decades ago, it was the rare patient with a functionally univentricular heart who
survived to adulthood. 1 While this grim prognosis has gradually improved over the years …

Stem cell therapy is promising for neural repair in devastating traumatic brain injury (TBI).
However, the low survival and differentiation rates of transplanted stem cells are main …

Objectives Staged surgical palliation for hypoplastic left heart syndrome results in an
increased workload on the right ventricle serving as the systemic ventricle. Concerns for …

Congenital heart disease is the number one cause of birth defect-related death because it
often leads to right ventricular heart failure (RVHF). One promising avenue to combat this …

Abstract Hypoplastic Left Heart Syndrome (HLHS) is a complex Congenital Heart Disease
(CHD) that was almost universally fatal until the advent of the Norwood operation in 1981 …

Stem/progenitor cells, including cardiac-derived c-kit+ progenitor cells (CPCs), are under
clinical evaluation for treatment of cardiac disease. Therapeutic efficacy of cardiac cell …

Pediatric heart failure (PHF) data has wide variation due to the scarcity of large multicenter
studies. Literature is based mostly on single-center publications. A systematic review by …

Mortality in infants with hypoplastic left heart syndrome (HLHS) is strongly correlated with
right ventricle (RV) dysfunction. Cell therapy has demonstrated potential improvements of …

Abstract Purpose of Review The lack of adult human cardiomyocyte proliferative capacity
impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized …