Iron has the capacity to accept and donate electrons readily, interconverting between ferric
(Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of …

Iron is vital for almost all living organisms by participating in a wide variety of metabolic
processes, including oxygen transport, DNA synthesis, and electron transport. However, iron …

Research advances defining how zinc is transported into and out of cells and organelles
have increased exponentially within the past five years. Research has progressed through …

We previously reported the disruption of the murine gene encoding the transcription factor
USF2 and its consequences on glucose-dependent gene regulation in the liver. We report …

With rare exceptions, virtually all studied organisms from Archaea to man are dependent on
iron for survival. Despite the ubiquitous distribution and abundance of iron in the biosphere …

We recently reported the hemochromatosis-like phenotype observed in our Usf2 knockout
mice. In these mice, as in murine models of hemochromatosis and patients with hereditary …

Maintenance of proper “labile iron” levels is a critical component in preserving homeostasis.
Iron is a vital element that is a constituent of a number of important macromolecules …

Iron overload is associated with increased diabetes risk. We therefore investigated the effect
of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients …

Hereditary hemochromatosis, characterized by iron overload in multiple organs, is one of the
most common genetic disorders among Caucasians. Hepcidin, which is synthesized in the …

Plasma iron circulates bound to transferrin (Trf), which solubilizes the ferric ion and
attenuates its reactivity. Diferric Trf interacts with cell-surface Trf receptor (Trfr) to undergo …