The proteolysis targeting chimeras (PROTACs) approach has attracted extensive attention in
the past decade, which represents an emerging therapeutic modality with the potential to …

Photopharmacology is a novel technology in drug design that aims at solving poor drug
selectivity. This technology is currently in the proof-of-concept phase and relies on the …

The metabotropic glutamate receptors (mGluRs) are family C, dimeric G protein–coupled
receptors (GPCRs), which play critical roles in synaptic transmission. Despite an increasing …

Numerous processes contribute to the regulation of G protein–coupled receptors (GPCRs),
but relatively little is known about rapid mechanisms that control signaling on the seconds …

Molecular photoswitches are the foundation of light-activated drugs. A key photoswitch is
azobenzene, which exhibits trans–cis isomerism in response to light. The thermal half-life of …

To develop tools to investigate the biological functions of butyrylcholinesterase (BChE) and
the mechanisms by which BChE affects Alzheimer's disease (AD), we synthesized several …

Traditional methods for site-specific drug delivery in the brain are slow, invasive, and difficult
to interface with recordings of neural activity. Here, we demonstrate the feasibility and …

Serotonin receptors play central roles in neuromodulation and are critical drug targets for
psychiatric disorders. Optical control of serotonin receptor subtypes has the potential to …

Despite the fact that roughly 40% of all US Food and Drug Administration (FDA)-approved
pharmacological therapeutics target G protein–coupled receptors (GPCRs), there remains a …

The field of photopharmacology of Class A GPCR ligands has recently attracted attention. In
this review we analyze 31 papers on currently available photoswitchable ligands for Class A …