[HTML][HTML] Dengue: a growing problem with new interventions
Dengue is the disease caused by 1 of 4 distinct, but closely related dengue viruses (DENV-1–
4) that are transmitted by Aedes spp. mosquito vectors. It is the most common arboviral …
4) that are transmitted by Aedes spp. mosquito vectors. It is the most common arboviral …
The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design
FA Rey, K Stiasny, MC Vaney, M Dellarole… - EMBO reports, 2018 - embopress.org
Zika and dengue viruses belong to the Flavivirus genus, a close group of antigenically
related viruses that cause significant arthropod‐transmitted diseases throughout the globe …
related viruses that cause significant arthropod‐transmitted diseases throughout the globe …
Antibody-dependent enhancement of severe dengue disease in humans
LC Katzelnick, L Gresh, ME Halloran, JC Mercado… - Science, 2017 - science.org
For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to
enhance viral replication in vitro and severe disease in animal models. Although suspected …
enhance viral replication in vitro and severe disease in animal models. Although suspected …
Insights into dengue immunity from vaccine trials
EE Ooi, S Kalimuddin - Science translational medicine, 2023 - science.org
The quest for an effective dengue vaccine has culminated in two approved vaccines and
another that has completed phase 3 clinical trials. However, shortcomings exist in each …
another that has completed phase 3 clinical trials. However, shortcomings exist in each …
Recent updates on correlates of vaccine-induced protection
SA Plotkin - Frontiers in Immunology, 2023 - frontiersin.org
Correlates of protection are key for vaccine development against any pathogen. In this paper
we summarize recent information about correlates for vaccines against dengue, Ebola …
we summarize recent information about correlates for vaccines against dengue, Ebola …
Antibody Fc characteristics and effector functions correlate with protection from symptomatic dengue virus type 3 infection
Preexisting cross-reactive antibodies have been implicated in both protection and
pathogenesis during subsequent infections with different dengue virus (DENV) serotypes …
pathogenesis during subsequent infections with different dengue virus (DENV) serotypes …
[HTML][HTML] Recent advances in understanding dengue
S Halstead - F1000Research, 2019 - ncbi.nlm.nih.gov
This is a selective review of recent publications on dengue clinical features, epidemiology,
pathogenesis, and vaccine development placed in a context of observations made over the …
pathogenesis, and vaccine development placed in a context of observations made over the …
Severe dengue in travellers: pathogenesis, risk and clinical management
S Halstead, A Wilder-Smith - Journal of travel medicine, 2019 - academic.oup.com
Rationale for review Dengue is a frequent cause of febrile illness among travellers and has
overtaken malaria as the leading cause of febrile illness for those traveling to Southeast …
overtaken malaria as the leading cause of febrile illness for those traveling to Southeast …
Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine
A Wilder-Smith, J Hombach, N Ferguson… - The Lancet infectious …, 2019 - thelancet.com
Summary The Strategic Advisory Group of Experts (SAGE) on Immunization advises WHO
on global policies for vaccines. In April, 2016, SAGE issued recommendations on the use of …
on global policies for vaccines. In April, 2016, SAGE issued recommendations on the use of …
Antibody-dependent enhancement of viral infections
R Kulkarni - Dynamics of immune activation in viral diseases, 2020 - Springer
Antiviral antibodies constitute an important component of the host immune response against
viral infections and serve to neutralize and reduce infectivity of the virus. However, these …
viral infections and serve to neutralize and reduce infectivity of the virus. However, these …