Biomolecular condensates and disease pathogenesis
Biomolecular condensates or membraneless organelles (MLOs) formed by liquid-liquid
phase separation (LLPS) divide intracellular spaces into discrete compartments for specific …
phase separation (LLPS) divide intracellular spaces into discrete compartments for specific …
Targeting stress granules in neurodegenerative diseases: A focus on biological function and dynamics disorders
M Fang, Y Liu, C Huang, S Fan - Biofactors, 2024 - Wiley Online Library
Stress granules (SGs) are membraneless organelles formed by eukaryotic cells in response
to stress to promote cell survival through their pleiotropic cytoprotective effects. SGs recruit a …
to stress to promote cell survival through their pleiotropic cytoprotective effects. SGs recruit a …
Hydrogen-bonded network of water in phase-separated biomolecular condensates
Biomolecular condensates formed via phase separation of intrinsically disordered
proteins/regions (IDPs/IDRs) and nucleic acids are associated with cell physiology and …
proteins/regions (IDPs/IDRs) and nucleic acids are associated with cell physiology and …
Intermolecular energy migration via homoFRET captures the modulation in the material property of phase-separated biomolecular condensates
Physical properties of biomolecular condensates formed via phase separation of proteins
and nucleic acids are associated with cell physiology and disease. Condensate properties …
and nucleic acids are associated with cell physiology and disease. Condensate properties …
Heterotypic Interactions of Amyloid β and the Islet Amyloid Polypeptide Produce Mixed Aggregates with Non-Native Fibril Structure
D Baghel, A Ghosh - The Journal of Physical Chemistry Letters, 2024 - ACS Publications
Amyloid aggregates are hallmarks of the pathology of a wide range of diseases, including
type 2 diabetes (T2D) and Alzheimer's disease (AD). Much epidemiological and …
type 2 diabetes (T2D) and Alzheimer's disease (AD). Much epidemiological and …
A novel nanocomposite drug delivery system for SARS-CoV-2 infections
To develop an inhalable drug delivery system, we synthesized poly (lactic-co-glycolic acid)
nanoparticles with Remdesivir (RDV NPs) as an antiviral agent against SARS-CoV-2 …
nanoparticles with Remdesivir (RDV NPs) as an antiviral agent against SARS-CoV-2 …
[HTML][HTML] TDP43 and huntingtin Exon-1 undergo a conformationally specific interaction that strongly alters the fibril formation of both proteins
Protein aggregation is a common feature of many neurodegenerative diseases. In
Huntington's disease, mutant huntingtin is the primary aggregating protein, but the …
Huntington's disease, mutant huntingtin is the primary aggregating protein, but the …
Amygdala-predominant α-synuclein pathology is associated with exacerbated hippocampal neuron loss in Alzheimer's disease
K Gawor, SO Tomé, R Vandenberghe… - Brain …, 2024 - academic.oup.com
Misfolded α-synuclein protein accumulates in 43–63% of individuals with symptomatic
Alzheimer's disease. Two main patterns of comorbid α-synuclein pathology have been …
Alzheimer's disease. Two main patterns of comorbid α-synuclein pathology have been …
Oligomerization‐mediated phase separation in the nucleoid‐associated sensory protein H‐NS is controlled by ambient cues
B Lukose, S Goyal, AN Naganathan - Protein Science, 2025 - Wiley Online Library
H‐NS, a nucleoid‐associated protein (NAP) from enterobacteria, regulates gene expression
by dynamically transducing environmental cues to conformational assembly and DNA …
by dynamically transducing environmental cues to conformational assembly and DNA …
[HTML][HTML] Co-Aggregation of TDP-43 with Other Pathogenic Proteins and Their Co-Pathologies in Neurodegenerative Diseases
LL Jiang, XL Zhang, HY Hu - International Journal of Molecular Sciences, 2024 - mdpi.com
Pathological aggregation of a specific protein into insoluble aggregates is a common
hallmark of various neurodegenerative diseases (NDDs). In the earlier literature, each NDD …
hallmark of various neurodegenerative diseases (NDDs). In the earlier literature, each NDD …