Mitochondria are essential for proper cellular function through their critical roles in ATP
synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic …

Abstract Neuronal Ca2+ homeostasis and Ca2+ signaling regulate multiple neuronal
functions, including synaptic transmission, plasticity, and cell survival. Therefore …

Ca2+ is a key intermediary in a variety of signalling pathways and undergoes dynamic
changes in its cytoplasmic concentration due to release from stores within the endoplasmic …

Delayed neuronal death following prolonged (10–15min) stimulation of Glu receptors is
known to depend on sustained elevation of cytosolic Ca2+ concentration ([Ca2+] i) which …

Summary Plasma membrane Ca 2+-ATPases (PMCAs), a family of P-type ATPases, extrude
Ca 2+ ions from the cytosol to the extracellular space and are considered to be key …

In many cell types, IP3 and ryanodine receptor (IP3R/RyR)-mediated Ca2+ mobilization from
the sarcoendoplasmic reticulum (ER/SR) results in an elevation of mitochondrial matrix …

In this review we describe the present knowledge about store operated Ca 2+ entry (SOCE)
in neurons and the proteins involved in this process: STIM, as well as Orai and TRP …

Transient receptor potential vanilloid receptor 1 (TRPV1)-mediated release of neuroactive
peptides and neurotransmitters from the peripheral and central terminals of primary sensory …

Spine Ca2+ triggers the induction of synaptic plasticity and other adaptive neuronal
responses. The amplitude and time course of Ca2+ signals specify the activation of the …

Mutations and duplication/triplication of the alpha-synuclein (αSyn)-coding gene have been
found to cause familial Parkinson's disease (PD), while genetic polymorphisms in the region …