The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

The innate immune landscape of the central nervous system (CNS), including the brain and
the retina, consists of different myeloid cell populations with distinct tasks to fulfill. Whereas …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease and the
proteins and pathways involved in the pathophysiology are not fully understood. Even less is …

Background: Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive
neurodegenerative condition with limited therapeutic options at present. Survival from …

Objective The neurodegenerative disease, amyotrophic lateral sclerosis (ALS), is a
heterogeneous clinical syndrome involving multiple molecular pathways. The development …

Objectives Neurochemical markers of amyotrophic lateral sclerosis (ALS) that reflect
underlying disease mechanisms might help in diagnosis, staging and prediction of outcome …

Objective To investigate the role of neuroinflammation in asymptomatic and symptomatic
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mutation carriers …

Objective Amyotrophic lateral sclerosis (ALS) is a complex disease with numerous
pathological mechanisms resulting in a heterogeneous patient population. Using …

Amyotrophic lateral sclerosis (ALS) is described as a fatal and rapidly progressive
neurodegenerative disorder caused by the degeneration of upper motor neurons in the …