Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration
S Stegen, N Van Gastel, G Carmeliet - Bone, 2015 - Elsevier
Bone has the unique capacity to heal without the formation of a fibrous scar, likely because
several of the cellular and molecular processes governing bone healing recapitulate the …
several of the cellular and molecular processes governing bone healing recapitulate the …
[HTML][HTML] Engineering vascularized and innervated bone biomaterials for improved skeletal tissue regeneration
Blood vessels and nerve fibers are distributed throughout the entirety of skeletal tissue, and
play important roles during bone development and fracture healing by supplying oxygen …
play important roles during bone development and fracture healing by supplying oxygen …
It takes two: endothelial-perivascular cell cross-talk in vascular development and disease
The formation of new blood vessels is a crucial step in the development of any new tissue
both during embryogenesis and in vitro models as without sufficient perfusion the tissue will …
both during embryogenesis and in vitro models as without sufficient perfusion the tissue will …
A perspective on the clinical translation of scaffolds for tissue engineering
Scaffolds have been broadly applied within tissue engineering and regenerative medicine to
regenerate, replace, or augment diseased or damaged tissue. For a scaffold to perform …
regenerate, replace, or augment diseased or damaged tissue. For a scaffold to perform …
Matrix composition regulates three-dimensional network formation by endothelial cells and mesenchymal stem cells in collagen/fibrin materials
Co-cultures of endothelial cells (EC) and mesenchymal stem cells (MSC) in three-
dimensional (3D) protein hydrogels can be used to recapitulate aspects of vasculogenesis …
dimensional (3D) protein hydrogels can be used to recapitulate aspects of vasculogenesis …
Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation
Functional cardiac tissue engineering holds promise as a candidate therapy for myocardial
infarction and heart failure. Generation of “strong-contracting and fast-conducting” cardiac …
infarction and heart failure. Generation of “strong-contracting and fast-conducting” cardiac …
Skeletal regeneration for segmental bone loss: vascularised grafts, analogues and surrogates
B Dalisson, B Charbonnier, A Aoude, M Gilardino… - Acta Biomaterialia, 2021 - Elsevier
Massive segmental bone defects (SBD) are mostly treated by removing the fibula and
transplanting it complete with blood supply. While revolutionary 50 years ago, this remains …
transplanting it complete with blood supply. While revolutionary 50 years ago, this remains …
Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches
Xenotransplantation of patient-derived samples in mouse models has been instrumental in
depicting the role of hematopoietic stem and progenitor cells in the establishment as well as …
depicting the role of hematopoietic stem and progenitor cells in the establishment as well as …
Biomaterials in co-culture systems: towards optimizing tissue integration and cell signaling within scaffolds
KG Battiston, JWC Cheung, D Jain, JP Santerre - Biomaterials, 2014 - Elsevier
Most natural tissues consist of multi-cellular systems made up of two or more cell types.
However, some of these tissues may not regenerate themselves following tissue injury or …
However, some of these tissues may not regenerate themselves following tissue injury or …
A low-speed centrifugation concept leads to cell accumulation and vascularization of solid platelet-rich fibrin: an experimental study in vivo
A Kubesch, M Barbeck, S Al-Maawi, A Orlowska… - Platelets, 2019 - Taylor & Francis
Platelet-rich fibrin (PRF) is generated from the patients' own venous blood by a single
centrifugation step without the additional use of anticoagulants. Based on the previously …
centrifugation step without the additional use of anticoagulants. Based on the previously …