Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for
its role in contractile activation. However, in recent years the critical role of Ca in other …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress‐induced cardiac
channelopathy that has a high mortality in untreated patients. Our understanding has grown …

Coordinated release of calcium (Ca2+) from the sarcoplasmic reticulum (SR) through
cardiac ryanodine receptor (RYR2) channels is essential for cardiomyocyte function. In …

The Ca2+ release channel ryanodine receptor 2 (RyR2) is required for excitation-contraction
coupling in the heart and is also present in the brain. Mutations in RyR2 have been linked to …

The endoplasmic reticulum (ER) is a morphologically and functionally diverse organelle
capable of integrating multiple extracellular and internal signals and generating adaptive …

Carvedilol is one of the most effective beta blockers for preventing ventricular
tachyarrhythmias in heart failure, but the mechanisms underlying its favorable antiarrhythmic …

Abstract Ryanodine receptors (RyRs)/Ca2+ release channels, on the endoplasmic and
sarcoplasmic reticulum of most cell types, are required for intracellular Ca2+ release …

Spontaneous Ca2+ release from intracellular stores is important for various physiological
and pathological processes. In cardiac muscle cells, spontaneous store overload–induced …