Calcium cycling and signaling in cardiac myocytes
DM Bers - Annu. Rev. Physiol., 2008 - annualreviews.org
Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for
its role in contractile activation. However, in recent years the critical role of Ca in other …
its role in contractile activation. However, in recent years the critical role of Ca in other …
Inherited Dysfunction of Sarcoplasmic Reticulum Ca2+ Handling and Arrhythmogenesis
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …
Cardiac ryanodine receptor calcium release deficiency syndrome
Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …
Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia
MJ Wleklinski, PJ Kannankeril… - The Journal of …, 2020 - Wiley Online Library
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress‐induced cardiac
channelopathy that has a high mortality in untreated patients. Our understanding has grown …
channelopathy that has a high mortality in untreated patients. Our understanding has grown …
Dantrolene rescues arrhythmogenic RYR2 defect in a patient‐specific stem cell model of catecholaminergic polymorphic ventricular tachycardia
CB Jung, A Moretti, M Mederos y Schnitzler… - EMBO molecular …, 2012 - embopress.org
Coordinated release of calcium (Ca2+) from the sarcoplasmic reticulum (SR) through
cardiac ryanodine receptor (RYR2) channels is essential for cardiomyocyte function. In …
cardiac ryanodine receptor (RYR2) channels is essential for cardiomyocyte function. In …
[HTML][HTML] Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice
SE Lehnart, M Mongillo, A Bellinger… - The Journal of …, 2008 - Am Soc Clin Investig
The Ca2+ release channel ryanodine receptor 2 (RyR2) is required for excitation-contraction
coupling in the heart and is also present in the brain. Mutations in RyR2 have been linked to …
coupling in the heart and is also present in the brain. Mutations in RyR2 have been linked to …
Endoplasmic reticulum Ca2+ handling in excitable cells in health and disease
GE Stutzmann, MP Mattson - Pharmacological reviews, 2011 - ASPET
The endoplasmic reticulum (ER) is a morphologically and functionally diverse organelle
capable of integrating multiple extracellular and internal signals and generating adaptive …
capable of integrating multiple extracellular and internal signals and generating adaptive …
Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release
Q Zhou, J Xiao, D Jiang, R Wang, K Vembaiyan… - Nature medicine, 2011 - nature.com
Carvedilol is one of the most effective beta blockers for preventing ventricular
tachyarrhythmias in heart failure, but the mechanisms underlying its favorable antiarrhythmic …
tachyarrhythmias in heart failure, but the mechanisms underlying its favorable antiarrhythmic …
Modulation of the ryanodine receptor and intracellular calcium
Abstract Ryanodine receptors (RyRs)/Ca2+ release channels, on the endoplasmic and
sarcoplasmic reticulum of most cell types, are required for intracellular Ca2+ release …
sarcoplasmic reticulum of most cell types, are required for intracellular Ca2+ release …
The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias
Spontaneous Ca2+ release from intracellular stores is important for various physiological
and pathological processes. In cardiac muscle cells, spontaneous store overload–induced …
and pathological processes. In cardiac muscle cells, spontaneous store overload–induced …