The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

Tumour heterogeneity in primary prostate cancer is a well-established phenomenon.
However, how the subclonal diversity of tumours changes during metastasis and …

Background Gene expression profiling has revolutionized our ability to molecularly classify
primary human tumors and significantly enhanced the development of novel tumor markers …

Spleen tyrosine kinase (Syk) is a cytoplasmic protein tyrosine kinase well known for its
ability to couple immune cell receptors to intracellular signaling pathways that regulate …

SYK (spleen tyrosine kinase) is well-characterized in the immune system as an essential
enzyme required for signaling through multiple classes of immune recognition receptors. As …

A longstanding goal in cellular mechanobiology has been to link dynamic biomolecular
processes underpinning disease or morphogenesis to spatio-temporal changes in …

SWI/SNF chromatin remodeling complexes regulate critical cellular processes, including cell-
cycle control, programmed cell death, differentiation, genomic instability, and DNA repair …

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies resistant to
current chemotherapies or radiotherapies, which makes it urgent to identify new therapeutic …

Background: SYK gene regulates the expression of SYK kinase (Spleen tyrosine kinase), an
important non-receptor protein-tyrosine kinase for immunological receptor-mediated …