[HTML][HTML] Opportunities of connectomic neuromodulation

A Horn, MD Fox - Neuroimage, 2020 - Elsevier
The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

Closing the loop on deep brain stimulation for treatment-resistant depression

AS Widge, DA Malone Jr, DD Dougherty - Frontiers in neuroscience, 2018 - frontiersin.org
Major depressive episodes are the largest cause of psychiatric disability, and can often
resist treatment with medication and psychotherapy. Advances in the understanding of the …

Connectivity profile predictive of effective deep brain stimulation in obsessive-compulsive disorder

JC Baldermann, C Melzer, A Zapf, S Kohl… - Biological …, 2019 - Elsevier
Background Deep brain stimulation for obsessive-compulsive disorder is a rapidly
developing treatment strategy for treatment-refractory patients. Both the exact target and …

Probabilistic mapping of deep brain stimulation: insights from 15 years of therapy

GJB Elias, A Boutet, SE Joel, J Germann… - Annals of …, 2021 - Wiley Online Library
Deep brain stimulation (DBS) depends on precise delivery of electrical current to target
tissues. However, the specific brain structures responsible for best outcome are still debated …

Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function

AS Widge, S Zorowitz, I Basu, AC Paulk… - Nature …, 2019 - nature.com
Deep brain stimulation (DBS) is a circuit-oriented treatment for mental disorders.
Unfortunately, even well-conducted psychiatric DBS clinical trials have yielded inconsistent …

Cingulate dynamics track depression recovery with deep brain stimulation

S Alagapan, KS Choi, S Heisig, P Riva-Posse… - Nature, 2023 - nature.com
Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term
symptom relief for treatment-resistant depression (TRD). However, achieving stable recovery …

Proceedings of the eighth annual deep brain stimulation think tank: advances in optogenetics, ethical issues affecting DBS research, neuromodulatory approaches for …

V Vedam-Mai, K Deisseroth, J Giordano… - Frontiers in Human …, 2021 - frontiersin.org
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to
address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters …

Optimized programming algorithm for cylindrical and directional deep brain stimulation electrodes

DN Anderson, B Osting, J Vorwerk… - Journal of neural …, 2018 - iopscience.iop.org
Objective. Deep brain stimulation (DBS) is a growing treatment option for movement and
psychiatric disorders. As DBS technology moves toward directional leads with increased …

[HTML][HTML] The anatomy of the human medial forebrain bundle: ventral tegmental area connections to reward-associated subcortical and frontal lobe regions

VA Coenen, LV Schumacher, C Kaller… - NeuroImage: Clinical, 2018 - Elsevier
Introduction Despite their importance in reward, motivation, and learning there is only sparse
anatomical knowledge about the human medial forebrain bundle (MFB) and the connectivity …

Evaluation of methodologies for computing the deep brain stimulation volume of tissue activated

G Duffley, DN Anderson, J Vorwerk… - Journal of neural …, 2019 - iopscience.iop.org
Objective. Computational models are a popular tool for predicting the effects of deep brain
stimulation (DBS) on neural tissue. One commonly used model, the volume of tissue …