The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

Hox genes encode evolutionarily conserved transcription factors that are essential for the
proper development of bilaterian organisms. Hox genes are unique because they are …

Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of
the three germ layers transform into an embryo that includes most of the major internal and …

Distant-acting tissue-specific enhancers, which regulate gene expression, vastly outnumber
protein-coding genes in mammalian genomes, but the functional importance of this …

As a powerful tool for chemical biology, bioorthogonal chemistry broadens the ways to
explore the mystery of life. In this field, transition metal catalysts (TMCs) have received much …

Oncogenic alterations to DNA are not transforming in all cellular contexts,. This may be due
to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic …

Limb development has long served as a model system for coordinated spatial patterning of
progenitor cells. Here, we identify a population of naive limb progenitors and show that they …

Unlike mammals, Xenopus laevis tadpoles have a high regenerative potential. To
characterize this regenerative response, we performed single-cell RNA sequencing after tail …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …

The concept of cell fate relates to the future identity of a cell, and its daughters, which is
obtained via cell differentiation and division. Understanding, predicting, and manipulating …