Despite the steady increase in the number of studies focusing on the development of tissue
engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack …

Neurotrophins (NTs) were first identified as target-derived survival factors for neurons of the
central and peripheral nervous system (PNS). They are known to control neural cell fate …

Interactions of adult neural stem cells (NSCs) with supportive vasculature appear critical for
their maintenance and function, although the molecular details are still under investigation …

The actions of BDNF (Brain-derived Neurotrophic Factor) in regulating neuronal
development and modulating synaptic activity have been extensively studied and well …

Depression is a major cause of morbidity and low quality of life among patients with
cardiovascular disease (CVD), and it is now considered as an independent risk factor for …

Pulpal and periapical diseases are the most common dental diseases. The traditional
treatment is root canal therapy, which achieves satisfactory therapeutic outcomes …

Purpose: To identify mechanisms and mediators of resistance to antiangiogenic therapy in
human glioblastoma. Experimental Design: We carried out microarray gene expression …

The latent regenerative potential of endogenous neural stem/progenitor cells (NSCs) in the
adult mammalian brain has been postulated as a likely source for neural repair. However …

Neurotrophins and their receptors are key molecules that are known to be critical in
regulating nervous system development and maintenance and have been recognized to be …

Injured growth plate is often repaired by bony tissue causing bone growth defects, for which
the mechanisms remain unclear. Because neurotrophins have been implicated in bone …