Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a
range of neurodegenerative diseases that are collectively referred to as tauopathies …

Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …

Corticobasal degeneration (CBD) is a neurodegenerative tauopathy—a class of disorders in
which the tau protein forms insoluble inclusions in the brain—that is characterized by motor …

Current criteria for the clinical diagnosis of pathologically confirmed corticobasal
degeneration (CBD) no longer reflect the expanding understanding of this disease and its …

Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous
human neurodegenerative diseases, including Alzheimer's disease, tangle-only dementia …

The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia
as their common denominator. In this review, we describe the biochemical and histological …

Tau, a microtubule-associated protein, is the main component of the intracellular filamentous
inclusions that are involved in neurodegenerative diseases known as tauopathies, including …

▪ Abstract The defining neuropathological characteristics of Alzheimer's disease are
abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent …

A clinically and pathologically heterogeneous type of frontotemporal lobar degeneration has
abnormal tau pathology in neurons and glia (FTLD-tau). Familial FTLD-tau is usually due to …

A working group supported by the Office of Rare Diseases of the National Institutes of Health
formulated neuropathologic criteria for corticobasal degeneration (CBD) that were …