Abstract Histone deacetylase 6 (HDAC6) is a class IIb histone deacetylase that contains two
catalytic domains and a zinc-finger ubiquitin binding domain (ZnF-UBP) domain. The …

Alzheimer's disease (AD) as the most prevalent dementia type has become one of the
greatest threats to the health and life of the elder people worldwide. Although there has …

Background Alzheimer's disease (AD) is a degenerative neurological disorder. Recent
studies have indicated that histone deacetylases (HDACs) are among the most prominent …

Abstract Alzheimer's disease (AD), one of the major tauopathies, is multifactorial with a
massive demand for disease-modifying treatments rather than symptom management. An …

Chromatin is the context for all DNA-based molecular processes taking place in the cell
nucleus. The initial chromatin structure at the site of the DNA damage determines both …

Background The infiltrative nature of human gliomas renders complete surgical removal of
tumors futile. Thus, illuminating mechanisms of their infiltrative properties may improve …

Background Epigenetic dysregulation has been implicated in the development and
progression of a variety of human diseases, but epigenetic changes are reversible, and …

Abstract Histone deacetylase 6 (HDAC6) belongs to a class of epigenetic targets that have
been found to be a key protein in the association between tumors and cardiovascular …

Background Alzheimer's disease (AD) is a degenerative neurological disorder. Recent
studies have indicated that histone deacetylases (HDACs) are among the most prominent …

Die Inhibition von HDAC6 hat sich ua bei der Behandlung von neurodegenerativen
Erkrankungen, Autoimmunerkrankungen und Tumorerkrankungen als nützlich erwiesen …