CTCF plays a vital role in chromatin structure and function. CTCF is ubiquitously expressed
and plays diverse roles in gene regulation, imprinting, insulation, intra/interchromosomal …

Long-range chromatin interactions control metazoan gene transcription. However, the
involvement of intra-and interchromosomal interactions in development and oncogenesis …

Aberrant activation of the TAL1 is associated with up to 60% of T-ALL cases and is involved
in CTCF-mediated genome organization within the TAL1 locus, suggesting that CTCF …

It has been appreciated for decades that somatic genomic alterations that change coding
sequences of proto-oncogenes, translocate enhancers/promoters near proto-oncogenes, or …

TAL1 is an important regulator of hematopoiesis and its expression is tightly controlled
despite complexities in its genomic organization. It is frequently misregulated in T-cell acute …

Retroviral vector-mediated stem cell gene therapy is a promising approach for the treatment
of hematopoietic disorders. However, genotoxic side effects from integrated vector …

Abstract The three-dimensional (3D) organization of the genome is highly dynamic,
changing during development and varying across different tissues and cell types. Recent …

Abstract Laminin alpha 1 (LAMA1) is a major component of the earliest basement
membranes in the mammalian embryo. Disruption of the murine Lama1 gene result in lethal …