The orchestration of mitochondria within the cell represents a critical aspect of cell biology.
At the center of this process is the outer mitochondrial membrane protein, Miro. Miro …

The expected increase in prevalence of Parkinson's disease (PD) as the most common
neurodegenerative movement disorder over the next years underscores the need for a …

MIRO (mitochondrial Rho GTPase) consists of two GTPase domains flanking two Ca 2+-
binding EF-hand domains. A C-terminal transmembrane helix anchors MIRO to the outer …

Mitochondria are organelles present in most eukaryotic cells, where they play major and
multifaceted roles. The classical notion of the main mitochondrial function as the …

MYO19 interacts with mitochondria through a C‐terminal membrane association domain
(MyMOMA). Specific mechanisms for localization of MYO19 to mitochondria are poorly …

Mitochondria and peroxisomes are highly dynamic, multifunctional organelles. Both perform
key roles for cellular physiology and homoeostasis by mediating bioenergetics …

Dysfunction in mitochondrial dynamics is believed to contribute to a host of neurological
disorders and has recently been implicated in cancer metastasis. The outer mitochondrial …

Non-bilaterian animals consist of four phyla; Porifera, Cnidaria, Ctenophora, and Placozoa.
These early-diverging animals are crucial for understanding the evolution of the entire …

Pseudoenzymes are emerging as significant mediators and regulators of signal
transduction. These proteins maintain enzyme folds and topologies, but are disrupted in the …

Miro GTPases are key components in the machinery responsible for transporting
mitochondria and peroxisomes along microtubules, and also play important roles in …