Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Significance: Cancer cells that are resistant to radiation and chemotherapy are a major
problem limiting the success of cancer therapy. Aggressive cancer cells depend on elevated …

Copper is an essential trace element that plays a critical role in a variety of basic biological
functions, and serves as a key component in a number of copper-dependent enzymes that …

Pharmacological vitamin C (VC) is a potential natural compound for cancer treatment.
However, the mechanism underlying its antitumor effects remains unclear. In this study, we …

Cancer development has been directly related to oxidative stress. During chemotherapy,
some cancer patients use dietary antioxidants to avoid nutritional deficiencies due to cancer …

Colorectal cancer is one of the global causes of cancer deaths. Cancer stem cells (CSCs)
inside the tumour niche responsible for metastasis and relapses, and hence need to be …

Abstract TP53 (p53) is a pivotal player in tumor suppression with fifty percent of all invasive
tumors displaying mutations in the TP53 gene. In the present study, we characterized colon …

Cancers of digestive tract such as colorectal cancer (CRC) and gastric cancer (GC) are the
most commonly detected types of cancer worldwide and their origin can be associated with …

Colorectal carcinoma is among the most common types of cancers. With this disease, diffuse
scattering in the abdominal area (peritoneal carcinosis) often occurs before diagnosis …

The use of metals in medicine has grown impressively in recent years as a result of greatly
advanced understanding of biologically active metal complexes and metal-containing …