Conotoxins: chemistry and biology
The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …
and defense, providing the basis for survival and rapid diversification of the now estimated …
Structure-function of neuronal nicotinic acetylcholine receptor inhibitors derived from natural toxins
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-
gated ion channels that mediate fast neurotransmission in the central and peripheral …
gated ion channels that mediate fast neurotransmission in the central and peripheral …
Conotoxins targeting nicotinic acetylcholine receptors: an overview
Marine snails of the genus Conus are a large family of predatory gastropods with an
unparalleled molecular diversity of pharmacologically active compounds in their venom …
unparalleled molecular diversity of pharmacologically active compounds in their venom …
Recent advances on marine mollusk-derived natural products: chemistry, chemical ecology and therapeutical potential
ZH Chen, YW Guo, XW Li - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2011–2021 Marine mollusks, which are well known as rich sources of diverse and
biologically active natural products, have attracted significant attention from researchers due …
biologically active natural products, have attracted significant attention from researchers due …
Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms
S Dutertre, A Nicke, VI Tsetlin - Neuropharmacology, 2017 - Elsevier
The nicotinic acetylcholine receptor (nAChR) represents the prototype of ligand-gated ion
channels. It is vital for neuromuscular transmission and an important regulator of …
channels. It is vital for neuromuscular transmission and an important regulator of …
α7-and α9-containing nicotinic acetylcholine receptors in the functioning of immune system and in pain
I Shelukhina, A Siniavin, I Kasheverov… - International Journal of …, 2023 - mdpi.com
Nicotinic acetylcholine receptors (nAChRs) present as many different subtypes in the
nervous and immune systems, muscles and on the cells of other organs. In the immune …
nervous and immune systems, muscles and on the cells of other organs. In the immune …
What we have gained from ibogaine: α3β4 nicotinic acetylcholine receptor inhibitors as treatments for substance use disorders
For decades, ibogaine─ the main psychoactive alkaloid found in Tabernanthe iboga─ has
been investigated as a possible treatment for substance use disorders (SUDs) due to its …
been investigated as a possible treatment for substance use disorders (SUDs) due to its …
Marine origin ligands of nicotinic receptors: Low molecular compounds, peptides and proteins for fundamental research and practical applications
I Kasheverov, D Kudryavtsev, I Shelukhina, G Nikolaev… - Biomolecules, 2022 - mdpi.com
The purpose of our review is to briefly show what different compounds of marine origin, from
low molecular weight ones to peptides and proteins, offer for understanding the structure …
low molecular weight ones to peptides and proteins, offer for understanding the structure …
Neuronal nicotinic acetylcholine receptor modulators from cone snails
Marine cone snails are a large family of gastropods that have evolved highly potent venoms
for predation and defense. The cone snail venom has exceptional molecular diversity in …
for predation and defense. The cone snail venom has exceptional molecular diversity in …
The role of defensive ecological interactions in the evolution of conotoxins
JR Prashanth, S Dutertre, AH Jin, V Lavergne… - Molecular …, 2016 - Wiley Online Library
Venoms comprise of complex mixtures of peptides evolved for predation and defensive
purposes. Remarkably, some carnivorous cone snails can inject two distinct venoms in …
purposes. Remarkably, some carnivorous cone snails can inject two distinct venoms in …