The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …
population, which corresponds to more than two billion individuals. Latent tuberculosis is …
How sisters grow apart: mycobacterial growth and division
KJ Kieser, EJ Rubin - Nature Reviews Microbiology, 2014 - nature.com
Mycobacterium tuberculosis, which is the aetiological agent of tuberculosis, owes much of its
success as a pathogen to its unique cell wall and unusual mechanism of growth, which …
success as a pathogen to its unique cell wall and unusual mechanism of growth, which …
Basic concepts of microarrays and potential applications in clinical microbiology
MB Miller, YW Tang - Clinical microbiology reviews, 2009 - Am Soc Microbiol
The introduction of in vitro nucleic acid amplification techniques, led by real-time PCR, into
the clinical microbiology laboratory has transformed the laboratory detection of viruses and …
the clinical microbiology laboratory has transformed the laboratory detection of viruses and …
A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen
Background Mycobacterium tuberculosis (Mtb) becomes dormant and phenotypically drug
resistant when it encounters multiple stresses within the host. Inability of currently available …
resistant when it encounters multiple stresses within the host. Inability of currently available …
Genome plasticity of BCG and impact on vaccine efficacy
To understand the evolution, attenuation, and variable protective efficacy of bacillus
Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been …
Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been …
Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum
Background Tuberculous sputum provides a sample of bacilli that must be eliminated by
chemotherapy and that may go on to transmit infection. A preliminary observation that …
chemotherapy and that may go on to transmit infection. A preliminary observation that …
Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues
A central feature of Mycobacterium tuberculosis (Mtb) pathogenesis is the ability of Mtb to
survive within macrophages (MØ). Despite its critical importance, our appreciation of the …
survive within macrophages (MØ). Despite its critical importance, our appreciation of the …
Mycobacterial PE/PPE proteins at the host‐pathogen interface
SL Sampson - Journal of Immunology Research, 2011 - Wiley Online Library
The mycobacterial PE/PPE proteins have attracted much interest since their formal
identification just over a decade ago. It has been widely speculated that these proteins may …
identification just over a decade ago. It has been widely speculated that these proteins may …
Confronting the scientific obstacles to global control of tuberculosis
DB Young, MD Perkins, K Duncan… - The Journal of clinical …, 2008 - Am Soc Clin Investig
Tuberculosis (TB) is a major threat to global health, recently exacerbated by the emergence
of highly drug-resistant forms of the disease-causing pathogen and synergy with HIV/AIDS …
of highly drug-resistant forms of the disease-causing pathogen and synergy with HIV/AIDS …
The resuscitation‐promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for …
BD Kana, BG Gordhan, KJ Downing… - Molecular …, 2008 - Wiley Online Library
Mycobacterium tuberculosis contains five resuscitation‐promoting factor (Rpf)‐like proteins,
RpfA‐E, that are implicated in resuscitation of this organism from dormancy via a mechanism …
RpfA‐E, that are implicated in resuscitation of this organism from dormancy via a mechanism …