Targeted therapies for lung cancer patients with oncogenic driver molecular alterations

AC Tan, DSW Tan - Journal of Clinical Oncology, 2022 - ascopubs.org
Lung cancer has traditionally been classified by histology. However, a greater
understanding of disease biology and the identification of oncogenic driver alterations has …

Toward personalized treatment approaches for non-small-cell lung cancer

M Wang, RS Herbst, C Boshoff - Nature medicine, 2021 - nature.com
Worldwide, lung cancer is the most common cause of cancer-related deaths. Molecular
targeted therapies and immunotherapies for non-small-cell lung cancer (NSCLC) have …

Machine learning in drug discovery: a review

S Dara, S Dhamercherla, SS Jadav, CHM Babu… - Artificial intelligence …, 2022 - Springer
This review provides the feasible literature on drug discovery through ML tools and
techniques that are enforced in every phase of drug development to accelerate the research …

Clinical trial design in the era of precision medicine

E Fountzilas, AM Tsimberidou, HH Vo, R Kurzrock - Genome medicine, 2022 - Springer
Recent rapid biotechnological breakthroughs have led to the identification of complex and
unique molecular features that drive malignancies. Precision medicine has exploited next …

Applications of machine learning in drug discovery and development

J Vamathevan, D Clark, P Czodrowski… - Nature reviews Drug …, 2019 - nature.com
Drug discovery and development pipelines are long, complex and depend on numerous
factors. Machine learning (ML) approaches provide a set of tools that can improve discovery …

Artificial intelligence and machine learning in precision and genomic medicine

S Quazi - Medical Oncology, 2022 - Springer
The advancement of precision medicine in medical care has led behind the conventional
symptom-driven treatment process by allowing early risk prediction of disease through …

Targeting the MAPK pathway in KRAS-driven tumors

M Drosten, M Barbacid - Cancer cell, 2020 - cell.com
KRAS mutations occur in a quarter of all of human cancers, yet no selective drug has been
approved to treat these tumors. Despite the recent development of drugs that block KRAS …

The biology and management of non-small cell lung cancer

RS Herbst, D Morgensztern, C Boshoff - Nature, 2018 - nature.com
Important advancements in the treatment of non-small cell lung cancer (NSCLC) have been
achieved over the past two decades, increasing our understanding of the disease biology …

Master protocols to study multiple therapies, multiple diseases, or both

J Woodcock, LM LaVange - New England Journal of Medicine, 2017 - Mass Medical Soc
Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Rare molecular subtypes of lung cancer

G Harada, SR Yang, E Cocco, A Drilon - Nature Reviews Clinical …, 2023 - nature.com
Oncogenes that occur in≤ 5% of non-small-cell lung cancers have been defined as 'rare';
nonetheless, this frequency can correspond to a substantial number of patients diagnosed …