[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic

C Diener, A Keller, E Meese - Trends in Genetics, 2022 - cell.com
MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …

[HTML][HTML] Role of microRNAs in translation regulation and cancer

S Oliveto, M Mancino, N Manfrini… - World journal of biological …, 2017 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are pervasively expressed and regulate most biological functions.
They function by modulating transcriptional and translational programs and therefore they …

miR-145 micelles mitigate atherosclerosis by modulating vascular smooth muscle cell phenotype

DD Chin, C Poon, J Wang, J Joo, V Ong, Z Jiang… - Biomaterials, 2021 - Elsevier
In atherosclerosis, resident vascular smooth muscle cells (VSMCs) in the blood vessels
become highly plastic and undergo phenotypic switching from the quiescent, contractile …

Tumor suppressor miRNA-204-5p regulates growth, metastasis, and immune microenvironment remodeling in breast cancer

BS Hong, HS Ryu, N Kim, J Kim, E Lee, H Moon… - Cancer research, 2019 - AACR
Various miRNAs play critical roles in the development and progression of solid tumors. In
this study, we describe the role of miR-204-5p in limiting growth and progression of breast …

[HTML][HTML] MicroRNAs: new players in the pathobiology of preeclampsia

KR Bounds, VL Chiasson, LJ Pan, S Gupta… - Frontiers in …, 2017 - frontiersin.org
Our understanding of how microRNAs (miRNAs) regulate gene networks and affect different
molecular pathways leading to various human pathologies has significantly improved over …

[HTML][HTML] The MSC-EV-microRNAome: a perspective on therapeutic mechanisms of action in sepsis and ARDS

CC Dos Santos, M Lopes-Pacheco, K English… - Cells, 2024 - mdpi.com
Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) have
emerged as innovative therapeutic agents for the treatment of sepsis and acute respiratory …

Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs

M Aslani, SS Mortazavi-Jahromi, A Mirshafiey - International …, 2021 - Elsevier
Abstract SARS-CoV-2, as the causative agent of COVID-19, is an enveloped positives-sense
single-stranded RNA virus that belongs to the Beta-CoVs sub-family. A sophisticated hyper …

The role of microvesicles and its active molecules in regulating cellular biology

YM Lv, J Tan, Y Miao, Q Zhang - Journal of Cellular and …, 2019 - Wiley Online Library
Cell‐derived microvesicles are membrane vesicles produced by the outward budding of the
plasma membrane and released by almost all types of cells. These have been considered …

[HTML][HTML] miR-208a in cardiac hypertrophy and remodeling

XH Huang, JL Li, XY Li, SX Wang, ZH Jiao… - Frontiers in …, 2021 - frontiersin.org
Various stresses, including pressure overload and myocardial stretch, can trigger cardiac
remodeling and result in heart diseases. The disorders are associated with high risk of …

Mechanisms of microRNAs in atherosclerosis

A Schober, C Weber - Annual Review of Pathology: Mechanisms …, 2016 - annualreviews.org
The maladaptation of endothelial cells to disturbed flow at arterial bifurcations increases
permeability for lipoproteins. Additional injury by chemically modified lipoproteins disrupts …