Clinical proton MR spectroscopy in central nervous system disorders
A large body of published work shows that proton (hydrogen 1 [1H]) magnetic resonance
(MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality …
(MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality …
Ion channels enable electrical communication in bacterial communities
The study of bacterial ion channels has provided fundamental insights into the structural
basis of neuronal signalling; however, the native role of ion channels in bacteria has …
basis of neuronal signalling; however, the native role of ion channels in bacteria has …
Glutamate and glutamine: a review of in vivo MRS in the human brain
Our understanding of the roles that the amino acids glutamate (Glu) and glutamine (Gln)
play in the mammalian central nervous system has increased rapidly in recent times. Many …
play in the mammalian central nervous system has increased rapidly in recent times. Many …
The vicious circle of hypometabolism in neurodegenerative diseases: ways and mechanisms of metabolic correction
Y Zilberter, M Zilberter - Journal of neuroscience research, 2017 - Wiley Online Library
Hypometabolism, characterized by decreased brain glucose consumption, is a common
feature of many neurodegenerative diseases. Initial hypometabolic brain state, created by …
feature of many neurodegenerative diseases. Initial hypometabolic brain state, created by …
Therapeutic use of the ketogenic diet in refractory epilepsy: what we know and what still needs to be learned
IM Zarnowska - Nutrients, 2020 - mdpi.com
Ketogenic diet (KD) has been used to treat epilepsy for 100 years. It is a high-fat, low-
carbohydrate, and sufficient-protein-for-growth diet that mimics the metabolic changes …
carbohydrate, and sufficient-protein-for-growth diet that mimics the metabolic changes …
Dietary medium chain triglycerides for management of epilepsy: New data from human, dog, and rodent studies
Many studies show that glucose metabolism in epileptic brain areas can be impaired.
Energy is crucial to maintain normal brain function, including ion and neurotransmitter …
Energy is crucial to maintain normal brain function, including ion and neurotransmitter …
13C MRS studies of neuroenergetics and neurotransmitter cycling in humans
In the last 25 years, 13 C MRS has been established as the only noninvasive method for the
measurement of glutamate neurotransmission and cell‐specific neuroenergetics. Although …
measurement of glutamate neurotransmission and cell‐specific neuroenergetics. Although …
Traumatic brain injury increases cortical glutamate network activity by compromising GABAergic control
D Cantu, K Walker, L Andresen, A Taylor-Weiner… - Cerebral …, 2015 - academic.oup.com
Traumatic brain injury (TBI) is a major risk factor for developing pharmaco-resistant epilepsy.
Although disruptions in brain circuitry are associated with TBI, the precise mechanisms by …
Although disruptions in brain circuitry are associated with TBI, the precise mechanisms by …
Copper signaling in the mammalian nervous system: synaptic effects
Copper is an essential metal present at high levels in the CNS. Its role as a cofactor in
mitochondrial ATP production and in essential cuproenzymes is well defined. Menkes and …
mitochondrial ATP production and in essential cuproenzymes is well defined. Menkes and …