Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …
The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited
RL Rosenfield, DA Ehrmann - Endocrine reviews, 2016 - academic.oup.com
Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian
hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989–1995 …
hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989–1995 …
Sheep models of polycystic ovary syndrome phenotype
V Padmanabhan, A Veiga-Lopez - Molecular and cellular endocrinology, 2013 - Elsevier
Polycystic ovary syndrome (PCOS) is a fertility disorder affecting 5–7% of reproductive-aged
women. Women with PCOS manifest both reproductive and metabolic defects. Several …
women. Women with PCOS manifest both reproductive and metabolic defects. Several …
Evidence-based hormonal, mutational, and endocrine-disrupting chemical-induced zebrafish as an alternative model to study PCOS condition similar to mammalian …
Polycystic ovarian syndrome (PCOS) causes swollen ovaries in women at reproductive age
due to hormonal disorder with small cysts on the outer edges. The cause of the disorder is …
due to hormonal disorder with small cysts on the outer edges. The cause of the disorder is …
Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring
M Hu, JE Richard, M Maliqueo… - Proceedings of the …, 2015 - National Acad Sciences
During pregnancy, women with polycystic ovary syndrome (PCOS) display high circulating
androgen levels that may affect the fetus and increase the risk of mood disorders in …
androgen levels that may affect the fetus and increase the risk of mood disorders in …
Pathogenesis of polycystic ovary syndrome: multifactorial assessment from the foetal stage to menopause
AS De Melo, SV Dias, R de Carvalho Cavalli… - …, 2015 - rep.bioscientifica.com
Polycystic ovary syndrome (PCOS) is a multifactorial disorder that arises from interactions
between genetic, environmental and intra-uterine factors. Small-for-gestational-age (SGA) …
between genetic, environmental and intra-uterine factors. Small-for-gestational-age (SGA) …
Developmental programming: gestational bisphenol-A treatment alters trajectory of fetal ovarian gene expression
A Veiga-Lopez, LJ Luense, LK Christenson… - …, 2013 - academic.oup.com
Abstract Bisphenol-A (BPA), a ubiquitous environmental endocrine disrupting chemical, is a
component of polycarbonate plastic and epoxy resins. Because of its estrogenic properties …
component of polycarbonate plastic and epoxy resins. Because of its estrogenic properties …
Animal models of the polycystic ovary syndrome phenotype
V Padmanabhan, A Veiga-Lopez - Steroids, 2013 - Elsevier
The etiology of the polycystic ovary syndrome (PCOS) remains unclear, despite its high
prevalence among infertility disorders in women of reproductive age. Although there is …
prevalence among infertility disorders in women of reproductive age. Although there is …
Circadian clock function in the mammalian ovary
MT Sellix - Journal of biological rhythms, 2015 - journals.sagepub.com
Rhythmic events in the female reproductive system depend on the coordinated and
synchronized activity of multiple neuroendocrine and endocrine tissues. This coordination is …
synchronized activity of multiple neuroendocrine and endocrine tissues. This coordination is …
Gestational hyperandrogenism in developmental programming
C Hakim, V Padmanabhan, AK Vyas - Endocrinology, 2017 - academic.oup.com
Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of
reproductive age. The potential causes of androgen excess in women include polycystic …
reproductive age. The potential causes of androgen excess in women include polycystic …