Liver fibrosis: mechanistic concepts and therapeutic perspectives
N Roehlen, E Crouchet, TF Baumert - Cells, 2020 - mdpi.com
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …
TGF-β in hepatic stellate cell activation and liver fibrogenesis—updated 2019
Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …
The power of plasticity—metabolic regulation of hepatic stellate cells
Hepatic stellate cells (HSCs) are resident non-parenchymal liver pericytes whose plasticity
enables them to regulate a remarkable range of physiologic and pathologic responses. To …
enables them to regulate a remarkable range of physiologic and pathologic responses. To …
Molecular pathways of nonalcoholic fatty liver disease development and progression
F Bessone, MV Razori, MG Roma - Cellular and Molecular Life Sciences, 2019 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …
Oxidative stress is a key modulator in the development of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, and scientific studies consistently report that NAFLD development can be …
worldwide, and scientific studies consistently report that NAFLD development can be …
Oxidative stress in liver pathophysiology and disease
The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …
not only arise during metabolic functions but also during the biotransformation of …
Transforming growth factor-β-induced cell plasticity in liver fibrosis and hepatocarcinogenesis
I Fabregat, D Caballero-Díaz - Frontiers in oncology, 2018 - frontiersin.org
The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …
different cellular processes that are essential for tissue and organ homeostasis. In the case …
TGF‐β signalling and liver disease
I Fabregat, J Moreno‐Càceres, A Sánchez… - The FEBS …, 2016 - Wiley Online Library
The transforming growth factor‐beta (TGF‐β) family signalling pathways play essential roles
in the regulation of different cellular processes, including proliferation, differentiation …
in the regulation of different cellular processes, including proliferation, differentiation …
TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
L Caja, F Dituri, S Mancarella… - International journal of …, 2018 - mdpi.com
Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic
response and for the activation of the cancer stroma. Strong evidence suggests that a strong …
response and for the activation of the cancer stroma. Strong evidence suggests that a strong …
[HTML][HTML] Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis
RM Liu, LP Desai - Redox biology, 2015 - Elsevier
Transforming growth factor beta (TGF-β) is the most potent pro-fibrogenic cytokine and its
expression is increased in almost all of fibrotic diseases. Although signaling through Smad …
expression is increased in almost all of fibrotic diseases. Although signaling through Smad …