Role of cardiolipin in mitochondrial signaling pathways

J Dudek - Frontiers in cell and developmental biology, 2017 - frontiersin.org
The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes
and plays a role in many mitochondrial processes, including respiration and energy …

Metabolic reprogramming in glioma

M Strickland, EA Stoll - Frontiers in cell and developmental biology, 2017 - frontiersin.org
Many cancers have long been thought to primarily metabolize glucose for energy production—
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …

Role of mitochondria in physiology of chondrocytes and diseases of osteoarthritis and rheumatoid arthritis

S Kan, M Duan, Y Liu, C Wang, J Xie - Cartilage, 2021 - journals.sagepub.com
Purpose of Review Mitochondria are recognized to be one of the most important organelles
in chondrocytes for their role in triphosphate (ATP) generation through aerobic …

Mitochondrial control by DRP1 in brain tumor initiating cells

Q Xie, Q Wu, CM Horbinski, WA Flavahan, K Yang… - Nature …, 2015 - nature.com
Brain tumor initiating cells (BTICs) co-opt the neuronal high affinity glucose transporter,
GLUT3, to withstand metabolic stress. We investigated another mechanism critical to brain …

Parkin and mitophagy in cancer

JP Bernardini, M Lazarou, G Dewson - Oncogene, 2017 - nature.com
Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the
homeostasis of a healthy network of functioning mitochondria and prevents excessive …

Mitochondrial dynamics and mitophagy in lung disorders

A Sharma, S Ahmad, T Ahmad, S Ali, MA Syed - Life sciences, 2021 - Elsevier
Mitochondria are biosynthetic, bioenergetic, and signaling organelles which are critical for
physiological adaptations and cellular stress responses to the environment. Various …

LKB1/AMPK pathway and drug response in cancer: a therapeutic perspective

F Ciccarese, E Zulato… - Oxidative medicine and …, 2019 - Wiley Online Library
Inactivating mutations of the tumor suppressor gene Liver Kinase B1 (LKB1) are frequently
detected in non‐small‐cell lung cancer (NSCLC) and cervical carcinoma. Moreover, LKB1 …

Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover

K Palikaras, I Daskalaki, M Markaki… - Pharmacology & …, 2017 - Elsevier
Mitochondria are highly dynamic and semi-autonomous organelles, essential for many
fundamental cellular processes, including energy production, metabolite synthesis, ion …

Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle

CE Fealy, A Mulya, N Lai… - Journal of Applied …, 2014 - journals.physiology.org
Defects in mitochondrial dynamics, the processes of fission, fusion, and mitochondrial
autophagy, may contribute to metabolic disease including type 2 diabetes. Dynamin-related …

Functional and morphological impact of ER stress on mitochondria

K Vannuvel, P Renard, M Raes… - Journal of cellular …, 2013 - Wiley Online Library
Over the past years, knowledge and evidence about the existence of crosstalks between
cellular organelles and their potential effects on survival or cell death have been constantly …