Publisher Summary This chapter summarizes the experimental findings and observations
based on the nonobese diabetic (NOD) mouse model and discusses the pathogenesis and …

Insulin-dependent diabetes mellitus (IDDM) is a disease that results from autoimmune
destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans. The …

Summary 1, 25 dihydroxyvitamin D 3, the active form of vitamin D, has immunomodulatory
properties in vitro and in vivo. We report that treatment with 1, 25 dihydroxyvitamin D 3 (5 …

Nonobese diabetic (NOD) mice genetically deficient in B lymphocytes (NOD. Igμ null) are
resistant to T cell-mediated autoimmune insulin-dependent diabetes mellitus (IDDM). Ig …

Precise definition of the role of both CD4 and CD8 T-cell subsets from NOD mice in the
adoptive transfer of diabetes has been complicated by the possibility that endogenous T …

" It is perhaps today, where a certain underevaluation-well, even disrespect-of scientific
research is growing-useful again and again to refer to the fact of how well suited the …

Who is more contemptible than he who scorns knowledge of himself?—John of Salisbury
bodies; and the autoreactive T cell dependence of IDDM pathogenesis and the ability to …

The discovery of the severe combined immunodeficiency (scid) mouse mutation has
provided a tool for establishment of small animal models as hosts for the in vivo analysis of …

Correlation studies between cytokines expressed in islets and autoimmune diabetes
development in NOD mice and BB rats have demonstrated that β‐cell destructive insulitis is …

Homozygosity for the severe combined immunodeficiency (scid) mutation results in a block
in T-and B-lymphocyte development. An unusually high incidence of spontaneous thymic …